[1]王润生 覃智斌△ 唐福宇 梁柱 王继.骨质疏松性椎体压缩骨折合并慢性阻塞性肺病治疗的回顾分析[J].中国中医骨伤科杂志,2016,24(05):25-28.
　WANG Runsheng QIN Zhibin TANG Fuyu LIANG Zhu WANG Ji.A Retrospective Analysis of Osteoporosis Vertebral Compression Fracture Combined with Chronic Obstructive Pulmonary Disease[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2016,24(05):25-28.
点击复制

骨质疏松性椎体压缩骨折合并慢性阻塞性肺病治疗的回顾分析
分享到：

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第24卷
期数:
2016年05期
页码:
25-28
栏目:
实验研究
出版日期:
2016-05-15

文章信息/Info

Title:
A Retrospective Analysis of Osteoporosis Vertebral Compression Fracture Combined with Chronic Obstructive Pulmonary Disease
文章编号:
1005-0205(2016)05-0025-04
作者:
王润生1 覃智斌1△ 唐福宇1 梁柱1 王继1
1.广西中医药大学第三附属医院(广西 柳州,545001)
△.通信作者 E-mail:run708@163.com
Author(s):
WANG Runsheng1 QIN Zhibin1△ TANG Fuyu1 LIANG Zhu1 WANG Ji1
1.The Third Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Liuzhou 545001,Guangxi China.
关键词:
骨质疏松性椎体压缩骨折;  慢性阻塞性肺病;  椎体成形术;  保守治疗
Keywords:
osteoporosis vertebral compression fracture;  chronic obstructive pulmonary disease;  percutaneous vertebroplasy;  conservative treatment
分类号:
R683.2
文献标志码:
A
摘要:
目的:探讨骨质疏松性椎体压缩骨折(Osteoporosis Vertebral Compression Fracture,OVCF)合并慢性阻塞性肺病(Chronic Obstructive Pulmonary Disease,COPD)的特点及治疗方法。方法:回顾分析OVCF合并COPD病例50例,共76椎,将获得随访的47例分为经皮椎体成形术(Percutaneous Vertebroplasy,PVP)组及保守治疗组,比较两组治疗前、治疗1周、1月、3月VAS,ODI评分。结果:50例患者平均年龄76.52岁,男性28例,女性22例; 病因:咳嗽17例,占34%,扭伤3例,占6%,跌伤10例,占20%,无明显诱因20例,占40%; 伤椎:单椎体33例,占66%,两椎体及以上17例,占34%,其中有3例患者出现4次再骨折,1例患者出现2次再骨折,其中3例因肺部感染、呼吸衰竭而死亡,占6%,余下的47例中PVP组14例,保守治疗组33例。治疗前两组VAS、ODI评分差异无统计学意义; 治疗1周、1月、3月VAS、ODI评分差异具有统计学意义,PVP组优于保守治疗组。结论:OVCF合并COPD易出现多节段骨折,再骨折发生率高,考虑可能与骨密度低有关,咳嗽是COPD诱发OVCF的重要因素,如无手术禁忌,建议尽早手术。
Abstract:
Objective:To summarize the characteristics and treatment of osteoporotic vertebral compression fractures(OVCF)combined with chronic obstructive pulmonary disease(COPD).Methods:50 cases of osteoporotic vertebral compression fractures with COPD cases were analyzed retrospectively,a total of 76 vertebrae.47 patients were divided into PVP group and conservative treatment group.VAS and ODI scores of the two groups were compared before treatment,1 week,1 month,and 3 months after treatment.Results:50 patients with an average age of 76.52 years,male 28 cases,female 22 cases.Cough in 17 cases,accounting for 34%,and 3 cases of sprain,accounted for 6%,Injuries in 10 cases,accounting for 20%,no obvious cause in 20 cases,and accounting for 40%.Single vertebra in 33 cases,accounted for 66%,two vertebrae and above 17,accounted for 34%.3 patients suffered from re fracture 4 times and patient re fracture 2 times.3 cases died due to pulmonary infection,respiratory failure,accounting for 6%.Among the remaining 47 cases,14 were in the PVP group and 33 cases in the conservative treatment group.There was no significant difference in VAS and ODI scores between the two groups before treatment.1 week,1 month and 3 months after treatment,VAS and ODI score was statistically significant difference between the two groups,PVP group is better than the conservative treatment group.Conclusion:Cough is an important factor in COPD induced OVCF.If there is no surgical contraindication,it is recommended to operate as early as possible.

参考文献/References:

[1] Li L,Brennan KJ,Gaughan JP,et al.African Americans and men with severe COPD have a high prevalence of osteoporosis[J].COPD,2008,5(5):291-297.
[2] 陈红,李为民.慢性阻塞性肺病和骨质疏松[J].国际内科学杂志,2008,35(11):653-656.
[3] 罗仲流,黄青松.30例老年COPD患者与骨质疏松症相关性研究[J].四川医学,2014,35(2):186-187.
[4] Kjensli A,Mowinckel P,Ryg MS,et al.Low bone mineral density is related to severity of chronic obstructive pulmonary disease[J].Bone,2007,40(2):493-497.
[5] Carlin BW.COPD and Associated Comorbidities:A Review of Current Diagnosis and Treatment[J].Postgraduate Medicine,2012,124(4):225-240.
[6] Jorgensen NR,Schwarz P,Holme I,et al.The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease:a cross sectional study[J].Respir Med,2007,101(1):177-185.
[7] 李俏俏.不同分期的COPD患者并发骨质疏松的相关因素分析[J].医学研究杂志,2014,43(8):150-155.
[8] 张培芳,罗志扬,冯彦林,等.慢性阻塞性肺疾病合并骨质疏松患者血清基质金属蛋白酶9和肿瘤坏死因子α与骨密度的关系[J].中国全科医学,2014,17(9):1009-1012.
[9] 黄妮雯,刘春涛,任旭斌,等.短期应用糖皮质激素对老年男性慢性阻塞性肺疾病急性加重期患者骨代谢的影响[J].西部医学,2011,23(1):24-27.
[10] 郭燕,李侠.老年慢性阻塞性肺病与骨质疏松相关性研究[J].临床肺科杂志,2011,16(11):1791-1792.
[11] Herman S,Schett N.Molecular mechanisms of inflammatory bone damage:emerging targets for therapy[J].Trends Mol Med,2008,14(6):245-253.
[12] Pinto-Plata V,Casanova C,Müllerova H,et al.Inflammatory and repair serum biomarker pattern:association to clinical outcomes in COPD[J].Respir Res,2012,13:71.
[13] Agusa AGN,Noguera A,Sauleda J,et al.Systemic effects of chronic obstructive pulmonary disease[J].Eur Respir J,2003,21:347-360.
[14] 陈光喜,杜丹丹,李军.老年男性慢性阻塞性肺疾病与骨质疏松生化指标及相关细胞因子的关系[J].中国医学创新,2013,10(27):3-5.
[15] Lehouck A,van Remoortel H,Troosters T,et al.BPCO et métabolisme osseux:une mise à jour clinique[J].Revue des Maladies Respiratoires,2010,27(10):1231-1242.

更新日期/Last Update: 2016-05-15