[1]秦立武 王友强 谭训香 姜红江△ 江和训 宋修刚.补肾健骨方对假体松动炎性因子IL-1、IL-6、 TNF-α抑制的实验研究[J].中国中医骨伤科杂志,2015,23(08):11-13.
　QING Liwu WANG Youqiang TAN Xunxiang JIANG Hongjiang JIANG Hexun SONG Xiugang.Study of Bushenjiangu Decoction on the Secretion of IL-1,IL-6, and TNF-α in Aseptic Loosening of Prostheses[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2015,23(08):11-13.
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补肾健骨方对假体松动炎性因子IL-1、IL-6、 TNF-α抑制的实验研究
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第23卷
期数:
2015年08期
页码:
11-13
栏目:
实验研究
出版日期:
2015-08-15

文章信息/Info

Title:
Study of Bushenjiangu Decoction on the Secretion of IL-1,IL-6, and TNF-α in Aseptic Loosening of Prostheses
文章编号:
1005-0205(2015)08-0011-03
作者:
秦立武1 王友强1 谭训香1 姜红江1△ 江和训1 宋修刚1
1.山东省文登整骨医院(山东 文登,264400)
△.通信作者 E-mail:boneman@163.com
Author(s):
QING Liwu1 WANG Youqiang1 TAN Xunxiang1 JIANG Hongjiang1 JIANG Hexun1 SONG Xiugang1
1.Wendeng Orthopedics Hospital of Shandong Province,Wendeng 264400,Shandong China.
关键词:
补肾健骨方;  IL-1;  IL-6;  TNF-α;  假体无菌性松动
Keywords:
Bushenjiangu decoction;  IL-1;  IL-6;  TNF-α;  aseptic loosening
分类号:
R-33
文献标志码:
A
摘要:
目的:观察中药补肾健骨方对致关节假体无菌性松动炎性因子IL-1,IL-6,TNF-α抑制作用。方法:人工髋关节翻修术中取出的假体界膜组织作为实验标本,将其放入RPMI培养液中培养,分空白对照组、低浓度补肾健骨方组(5%)、高浓度补肾健骨方组(20%),培养72 h,取上清液,酶联法测定IL-1,IL-6,TNF-α.结果:与对照组相比,5%、20%补肾健骨方组均能显著抑制界膜细胞分泌IL-1,IL-6,TNF-α(P<0.05)。结论:补肾健骨方能显著抑制假体周围界膜细胞分泌IL-1,IL-6,TNF-α.
Abstract:
Objective:To observe the effect of Bushenjiangu decoction on the secretion of IL-1,IL-6,and TNF-α in aseptic loosening of prostheses.Methods:The periprosthetic membrane organization was taken through the revision hip arthroplasty,which were cultured in RPMI-1640 medium.They were divided into control group,low concentration of Bushenjiangu decoction group(5%),and high concentration of Bushenjiangu decoction group(20%).The concentration of IL-1,IL-6,and TNF-α was measured using ELISA methods 72 h after cultivation.Results:The secretion of IL-1,IL-6,and TNF-α were all significantly inhibited in both low and high concentration of Bushenjiangu decoction group compared to the control group(P<0.05).Conclusion:Bushenjiangu decoction is effective for inhibiting the secretion of IL-1,IL-6,and TNF-α in the interface membrane of prostheses.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2014-05-01
更新日期/Last Update: 2015-08-15