[1]冯晶 黄觅△ 倪欢 杜世阳 夏平.同型半胱氨酸水平对四肢骨折愈合的影响[J].中国中医骨伤科杂志,2015,23(07):38-41.
　FENG Jing HUANG Mi NI Huan DU Shiyang XIA Ping.Influence of Bone Healing by Homocysteine Levels on Patients with Limb Fracture[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2015,23(07):38-41.
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同型半胱氨酸水平对四肢骨折愈合的影响
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第23卷
期数:
2015年07期
页码:
38-41
栏目:
临床研究
出版日期:
2015-07-15

文章信息/Info

Title:
Influence of Bone Healing by Homocysteine Levels on Patients with Limb Fracture
文章编号:
1005-0205(2015)07-0038-04
作者:
冯晶1 黄觅1△ 倪欢1 杜世阳2 夏平1
1.湖北省武汉市第一医院骨科(武汉,430022)
2.湖北中医药大学
△.通信作者 E-mail:14590568@qq.com
Author(s):
FENG Jing1 HUANG Mi1 NI Huan1 DU Shiyang2 XIA Ping1
1.Department of Orthopedics, Wuhan No.1 Hospital, Wuhan 430022, China;
2.Hubei University of Traditional Chinese Medicine,Wuhan 430061,China
关键词:
四肢骨折;  高同型半胱氨酸血症;  维生素B6;  维生素B12;  叶酸
Keywords:
limb fracture;  hyperhomocysteinemia;  vitamin B6;  vitamin B12;  folic acid
分类号:
R683.4
文献标志码:
A
摘要:
目的:探讨同型半胱氨酸水平(Hcy)对四肢骨折愈合时间的影响及叶酸、维生素B6、B12干预的结果。方法:选取2012年1月-2014年8月我院收治的四肢骨折合并高同型半胱氨酸血症(Hhcy)患者167例,根据其出生月份末位数字的单双分组,双数者分至对照组,85例,单数者分至治疗组,82例,同期收集在我院收治的85例四肢骨折Hcy正常者作为正常组。三组患者给予常规综合治疗和护理,治疗组患者在此基础上加用小剂量叶酸联合维生素B6、B12治疗,均连续治疗3个月。比较三组治疗前后Hcy水平,骨折愈合时间与骨折愈合率。结果:治疗后3个月,治疗组血浆Hcy较治疗前明显下降(P<0.01),与正常组比较差异无统计学意义(P>0.05),均低于对照组Hcy水平(P<0.05); 对照组患者骨折愈合时间长于治疗组与正常组,骨折愈合率低于治疗组与正常组,差异均有统计学意义(P<0.05); 但治疗组与正常组在骨折愈合时间、骨折愈合率方面比较,差异无统计学意义(P>0.05); 对照组患者血浆Hcy水平与骨折愈合时间呈线性相关(r=0.821,P=0.000)。结论:Hhcy延长骨折愈合时间,应用叶酸、维生素B6、B12可以减轻Hhcy对四肢骨折愈合的影响。
Abstract:
Objective: To explore the influence of homocysteine(Hhcy)levels on bone healing of patients with limb fracture and to detect the intervention effect of folic acid, vitamin B6, and vitamin B12. Methods: All 167 cases of Hhcy patients with limb fracture were randomly divided into test group(85 cases)and treatment group(82 cases)from January 2012 to August 2014. As while, 85 cases of normal Hcy patients with limb fracture were collected as control group. All patients of the three groups were given conventional therapy. The patients in the treatment group were additional given small dose of folic acid combined with vitamin therapy continuously for 3 months. The Hcy levels, the healing time, and healing rate of fracture in the three groups were compared before and after treatment. Results: The Hcy levels in the treatment group were lower 3 months after treatment, but there was no significant difference in the control group(P>0.05). The Hcy levels of both treatment group and control group were lower than the test group(P<0.01).The fracture healing time of the test group was longer than the treatment group and the control group. The fracture healing rate was lower than the other two groups(P<0.05). The fracture healing time and rate was not significantly different between treatment group and the control group(P>0.05). The fracture healing time was linearly correlated with the Hcy level in the test group(r=0.821, P=0.000). Conclusions: Hcy level is affect the fracture healing. The folic acid, vitamin B6, and vitamin B12 can reduce adverse effects of Hhcy.

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备注/Memo

备注/Memo:
收稿日期:2014-06-09
基金项目:武汉市卫生计生委医疗卫生科研项目(WZ15C02)
湖北省自然科学基金项目(2014cfc1041)
更新日期/Last Update: 2015-07-10