参考文献/References:
[1] 冯晓晴,蔡道章,余星磊,等.基于GBD大数据中国膝骨关节炎疾病负担现状与趋势分析[J].现代预防医学,2022,49(10):1753-1760.
[2] BABAEI M,JAVADIAN Y,NARIMANI H,et al.Correlation between systemic markers of inflammation and local synovitis in knee osteoarthritis[J].Caspian Journal of Internal Medicine,2019,10(4):383-387.
[3] 张鹏,荆琳,邸冬雪,等.关节镜下自体骨软骨移植并服温阳益髓方修复膝骨关节炎的软骨缺损[J].中国组织工程研究,2020,24(26):4135-4140.
[4] 张建,初培罡,杨楠楠,等.膝关节软骨损伤疾病治疗方法研究进展[J].中国当代医药,2023,30(17):32-35.
[5] 邸冬雪,艾奇,闫奇,等.补肾除湿联合富血小板血浆调控血清TGF-β1及Smad-1水平治疗膝骨关节炎[J].中国骨伤,2023,36(7):647-653.
[6] 何名江,张洪美,单鹏程,等.补肾除湿方治疗早期肝肾亏虚型膝骨关节炎的临床研究[J].中华中医药杂志,2020,35(4):2109-2113.
[7] MARTINEZ-SANCHEZ A,DUDEK K A,MURPHY C L.Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145(miRNA-145)[J].Journal of Biological Chemistry,2012,287(2):916-924.
[8] VAN ASSCHE D,STAES F,VAN CASPEL D,et al.Autologous chondrocyte implantation versus microfracture for knee cartilage injury:a prospective randomized trial,with 2-year follow-up[J].Knee Surgery,Sports Traumatology,Arthroscopy,2010,18(4):486-495.
[9] BAE D K,YOON K H,SONG S J.Cartilage healing after microfracture in osteoarthritic knees[J].Arthroscopy:the Journal of Arthroscopic & Related Surgery,2006,22(4):367-374.
[10] DOZIN B,MALPELI M,CANCEDDA R,et al.Comparative evaluation of autologous chondrocyte implantation and mosaicplasty:a multicentered randomized clinical trial[J].Clinical Journal of Sport Medicine,2005,15(4):220-226.
[11] BUCKWALTER J A,MANKIN H J.Articular cartilage:degeneration and osteoarthrosis,repair,regeneration,and transplantation[J].Instructional Course Lectures,1998,47:487-504.
[12] AHMAD RAEISSADAT S,RAYEGANI S M,HASSANABADI H,et al.Knee osteoarthritis injection choices:platelet-rich plasma(PRP)versus hyaluronic acid(a one-year randomized clinical trial)[J].Clinical Medicine Insights:Arthritis and Musculoskeletal Disorders,2015,8:S17894.
[13] BALTZER A W A,OSTAPCZUK M S,TERHEIDEN H P,et al.Good short- to medium-term results after osteochondral autograft transplantation(OAT)in middle-aged patients with focal,non-traumatic osteochondral lesions of the knee[J].Orthopaedics & Traumatology:Surgery & Research,2016,102(7):879-884.
[14] ULSTEIN S,ÅRØEN A,RØTTERUD J H,et al.Microfracture technique versus osteochondral autologous transplantation mosaicplasty in patients with articular chondral lesions of the knee:a prospective randomized trial with long-term follow-up[J].Knee Surgery,Sports Traumatology,Arthroscopy,2014,22(6):1207-1215.
[15] YABUMOTO H,NAKAGAWA Y,MUKAI S,et al.Osteochondral autograft transplantation for isolated patellofemoral osteoarthritis[J].The Knee,2017,24(6):1498-1503.
[16] CAMERON M,CHRUBASIK S A.Oral herbal therapies for treating osteoarthritis[J].The Cochrane Database of Systematic Reviews,2014,5:CD002947.
[17] LIU L L,XU L M,WANG S J,et al.Confirmation of inhibitingTLR4/MyD88/NF-κB signalling pathway by Duhuo Jisheng decoction on osteoarthritis:a network pharmacology approach-integrated experimental study[J].Frontiers in Pharmacology,2022,12:784822.
[18] WANG P E,ZHANG L,YING J,et al.Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling[J].Journal of Translational Medicine,2018,16(1):72.
[19] XU J B,SUN Q,QIU M,et al.Exploring the pharmacological mechanism of Glycyrrhiza uralensis against KOA through integrating network pharmacology and experimental assessment[J].Journal of Cellular and Molecular Medicine,2024,28(9):e18319.
[20] 张斌,代凤雷,尹宏,等.地黄梓醇干预早期膝骨关节炎大鼠膝关节滑膜组织中炎症相关因子的表达[J].中国组织工程研究,2020,24(29):4656-4661.
[21] 孙必强,张鸣,李美珍,等.威灵仙注射液关节腔离子导入对骨关节炎软骨和滑膜组织形态以及软骨MMP-1的影响[J].中医临床研究,2014,6(17):1-3.
[22] NIAZI F,RAHMAN A,BATOOL U.Hyperhomocysteinemia presenting with complete unilateral intracranial and extracranial carotid occlusion in a young patient[J].Journal of the College of Physicians and Surgeons Pakistan,2017,27(9):S101-S103.
[23] FURUMATSU T,MATSUMOTO-OGAWA E,TANAKA T,et al.ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes[J].Connective Tissue Research,2014,55(2):89-95.
[24] VAN DEN BERG W B.Osteoarthritis year 2010 in review:pathomechanisms[J].Osteoarthritis and Cartilage,2011,19(4):338-341.
[25] YAMAIRI F,UTSUMI H,ONO Y,et al.Expression of vascular endothelial growth factor(VEGF)associated with histopathological changes in rodent models of osteoarthritis[J].Journal of Toxicologic Pathology,2011,24(2):137-142.
[26] RÜBENHAGEN R,SCHÜTTRUMPF J P,STÜRMER K M,et al.Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis[J].Acta Orthopaedica,2012,83(1):59-64.
[27] KRAAN M C,REECE R J,BARG E C,et al.Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis:findings in a prospective,randomized,double-blind,parallel-design clinical trial in thirty-nine patients at two centers[J].Arthritis & Rheumatism,2000,43(8):1820-1830.
[28] KEYSZER G,LAMBIRI I,NAGEL R,et al.Circulating levels of matrix metalloproteinases MMP-3 and MMP-1,tissue inhibitor of metalloproteinases 1(TIMP-1)and MMP-1/TIMP-1 complex in rheumatic disease:correlation with clinical activity of rheumatoid arthritis versus other surrogate markers[J].Journal of Rheumatology,1999,26(2):251-258.
[29] SMEETS T M,KRAAN M C,GALJAARD S,et al.Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA[J].Annals of the Rheumatic Diseases,2001,60(6):561-565.
[30] 张洪美,李劲,何名江,等.温阳益髓方对兔膝骨关节炎模型骨髓干细胞动员和分化的影响[J].中国骨与关节损伤杂志,2014,29(5):468-471.
[31] 邹怡,潘良,蔡素芬,等.温针灸联合塞来昔布胶囊对膝骨关节炎患者骨代谢指标和血清IL-6、IL-17、IL-18水平的影响[J].现代生物医学进展,2022,22(6):1074-1078.
[32] TANG Y H,LI Y F,XIN D W,et al.Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling[J].Bioengineered,2021,12(1):2984-2999.
(收稿日期:2025-11-25)