[1]刘利坤,陈浩,兰海,等.多器官芯片:中医理论现代化阐释的创新方法[J].中国中医骨伤科杂志,2026,34(07):76-83.[doi:10.20085/j.cnki.issn1005-0205.260710]
　LIU Likun,CHEN Hao,LAN Hai,et al.Multi-Organ-on-a-chip:An Innovative Approach to the Modern Interpretation of Traditional Chinese Medicine Theories[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2026,34(07):76-83.[doi:10.20085/j.cnki.issn1005-0205.260710]
点击复制

多器官芯片:中医理论现代化阐释的创新方法()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第34卷
期数:
2026年07期
页码:
76-83
栏目:
学者论坛
出版日期:
2026-07-15

文章信息/Info

Title:
Multi-Organ-on-a-chip:An Innovative Approach to the Modern Interpretation of Traditional Chinese Medicine Theories
文章编号:
1005-0205(2026)07-0076-08
作者:
刘利坤1; 陈浩1; 兰海1; 宦想1; 刘成林1; 付佳豪1; 刘锌1; 孙鹏飞1; 闵文1△
1南京中医药大学附属医院(南京,210029)
Author(s):
LIU Likun1; CHEN Hao1; LAN Hai1; HUAN Xiang1; LIU Chenglin1; FU Jiahao1; LIU Xin1; SUN Pengfei1; MIN Wen1△
1Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China.
关键词:
多器官芯片;  中医理论现代化;  藏象学说;  疾病机理;  中药复方
Keywords:
multi-organ-on-a-chip;  modernization of traditi- onal Chinese medicine theory;  theory of visceral manifestations;  disease mechanism;  traditional Chinese medicine compounds
分类号:
R318
DOI:
10.20085/j.cnki.issn1005-0205.260710
文献标志码:
A
摘要:
中医理论科学性的现代化阐释面临抽象性和科学系统量化体系匮乏等难题。器官芯片(Organ-on-a-Chip,OC)在器官功能具象化和功能串联或并联展现方面具有可视化、可量化的优势,近年来,随着多器官芯片(Multi-Organ-on-a-Chip,MOC)技术方法的发展,可模拟多器官功能及相互作用的“系统芯片”为中医理论科学性的现代化阐释带来新契机。详细阐述多器官芯片的构成与优势,深入剖析中医理论现代化面临的挑战,从中医生理(藏象学说、五行学说)、病理(病因理论、病机理论、疾病转归)及治疗(治疗原则、中药复方)等维度,全面探讨多器官芯片在中医领域的应用价值。尽管目前多器官芯片技术在脏器复杂功能的连接整合及临床转化方面仍存在很多挑战,但该技术无疑有望为中医理论现代化研究提供创新思路与方法,助力揭示中医理论科学内涵,加速推动中医现代化进程。
Abstract:
The modern interpretation of the scientific nature of traditional Chinese medicine(TCM)theory faces challenges such as its abstractness and the lack of a scientific and systematic quantification system.Organ-on-a-Chip(OC)technology has the advantages of visualization and quantifiability in terms of materializing organ functions and presenting series-parallel connections of functions.In recent years,with the development of Multi-Organ-on-a-Chip(MOC)technology,the “system-on-a-chip” that can simulate the functions and interactions of multiple organs has brought new opportunities for the modern interpretation of the scientific nature of TCM theory.This article elaborates in detail on the composition and advantages of MOC,deeply analyzes the challenges confronting the modernization of TCM theory,and comprehensively explores the application value of MOC in the field of TCM from the aspects of TCM physiology(the theory of visceral manifestations and the theory of five elements),pathology(the theory of etiology,the theory of pathogenesis,and disease prognosis),and treatment(TCM treatment principles and TCM compounds).Although MOC technology still faces many challenges in the connection and integration of complex organ functions and translating them into clinical transformation,this technology undoubtedly holds promise in providing innovative ideas and methods for the modern research of TCM theory,helping to reveal the scientific connotation of TCM theory,and accelerating the modernization process of TCM.

参考文献/References:

[1] 刘争强,章文春.气本质研究之“四辩”[J].中华中医药杂志,2024,39(4):1618-1622.
[2] 梁茂新.论现代概念语境下的中医学异化[J].中华中医药杂志,2024,39(4):1683-1691.
[3] WANG K,LI G Z,YANG Z,et al.Compound Chinese medicine(F1)improves spleen deficiency diarrhea by protecting the intestinal mucosa and regulating the intestinal flora[J].Frontiers in Microbiology,2024,14:1292082.
[4] YAN S Y.Thoughts on the construction of flagship hospitals of integrated traditional Chinese and Western medicine in China[J].Journal of Integrative Medicine,2025,23(1):12-14.
[5] DOS SANTOS FERREIRA R R,ORTEGA F.Sobre o reducionismo na pesquisa do trauma [On reductionism in trauma research][J].Cadernos de Saúde Pública,2025,41:e00226524.
[6] MÉNDEZ-VIDAL C,BRAVO-GIL N,PÉREZ-FLORIDO J,et al.A genomic strategy for precision medicine in rare diseases:integrating customized algorithms into clinical practice[J].Journal of Translational Medicine,2025,23(1):86.
[7] PUN J,CHOR W.Use of questioning between traditional Chinese medicine practitioners and patients to realize TCM philosophy:holism,five elements and Yin-Yang in the context of doctor-patient communication[J].Health Communication,2022,37(2):163-176.
[8] WANG Y Y,LIU M X,JAFARI M,et al.A critical assessment of traditional Chinese medicine databases as a source for drug discovery[J].Frontiers in Pharmacology,2024,15:1303693.
[9] JIASHUO W U,ZHANG F Q,ZHUANGZHUANG L I,et al.Integration strategy of network pharmacology in traditional Chinese medicine:a narrative review[J].Journal of Traditional Chinese Medicine,2022,42(3):479-486.
[10] WANG Y L,SHI X M,LI L,et al.The impact of artificial intelligence on traditional Chinese medicine[J].The American Journal of Chinese Medicine,2021,49(6):1297-1314.
[11] GUO R,ZENG D,ZHAO Q,et al.How are different traditional Chinese medicine modalities deployed by clinical practitioners in China? Findings from a national survey[J].Journal of Integrative Medicine,2025,23(1):36-45.
[12] 世界中医药学会联合会,呼吸疾病中医药防治省部共建协同创新中心,河南中医药大学,等.中医证候诊断标准研制指南[J].中国循证医学杂志,2023,23(9):993-998.
[13] 李建生,冯贞贞,谢洋,等.病证结合模式下中医证候疗效评价量表研制的实践与策略[J].中国全科医学,2022,25(20):2513-2519.
[14] 田夏,柴倩云,张丽娟,等.不同医生辨证与针刺处方差异的临床研究[J].中医杂志,2017,58(6):498-501.
[15] BENSOUSSAN A,TALLEY N J,HING M,et al.Treatment of irritable bowel syndrome with Chinese herbal medicine:a randomized controlled trial[J].JAMA,1998,280(18):1585-1589.
[16] INGBER D E.Human organs-on-chips for disease modelling,drug development and personalized medicine[J].Nature Reviews Genetics,2022,23(8):467-491.
[17] VUNJAK-NOVAKOVIC G,RONALDSON-BOUCHARD K,RADISIC M.Organs-on-a-chip models for biological research[J].Cell,2021,184(18):4597-4611.
[18] SHROFF T,AINA K,MAASS C,et al.Studying metabolism with multi-organ chips:new tools for disease modelling,pharmacokinetics and pharmacodynamics[J].Open Biology,2022,12(3):210333.
[19] HABANJAR O,DIAB-ASSAF M,CALDEFIE-CHEZET F,et al.3D cell culture systems:tumor application,advantages,and disadvantages[J].International Journal of Molecular Sciences,2021,22(22):12200.
[20] LIU X X,SU Q P,ZHANG X Y,et al.Recent advances of organ-on-a-chip in cancer modeling research[J].Biosensors,2022,12(11):1045.
[21] PULLEN K M,FINETHY R,KO S B,et al.Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection[J].NPJ Systems Biology and Applications,2025,11(1):19.
[22] ÖZTÜRK A,ERSAN Ö.Are the lives of animals well-spent in laboratory science research?A study of orthopaedic animal studies in Turkey[J].Clinical Orthopaedics and Related Research,2020,478(9):1965-1970.
[23] FRÜHWEIN H,PAUL N W.“Lost in translation?” Animal research in the era of precision medicine[J].Journal of Translational Medicine,2025,23(1):152.
[24] SAJIN D,MOONSHI S S,CHA H T,et al.Multi-organ-on-a-chip:the gut and inflammatory diseases[J].ACS Biomaterials Science & Engineering,2025,11(9):5330-5342.
[25] HUANG S Y,HUANG F Y,YANG L W,et al.Shentao Ruangan granule ameliorates cholestatic liver disease via a microbiota-dependent gut-liver axis[J].Journal of Ethnopharmacology,2026,359:121069.
[26] PALMA-FLOREZ S,LAGUNAS A,MIR M.Neurovascular unit on a chip:the relevance and maturity as an advanced in vitro model[J].Neural Regeneration Research,2024,19(6):1165-1166.
[27] CECEN B,KARAVASILI C,NAZIR M,et al.Multi-organs-on-chips for testing small-molecule drugs:challenges and perspectives[J].Pharmaceutics,2021,13(10):1657.
[28] BANAEIYAN A A,THEOBALD J,PAUKTYTE J,et al.Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform[J].Biofabrication,2017,9(1):015014.
[29] DU Y,LI N,YANG H,et al.Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip[J].Lab on a Chip,2017,17(5):782-794.
[30] DU Y,KHANDEKAR G,LLEWELLYN J,et al.A bile duct-on-a-chip with organ-level functions[J].Hepatology,2020,71(4):1350-1363.
[31] WANG Y Q,WANG P,QIN J H.Microfluidic organs-on-a-chip for modeling human infectious diseases[J].Accounts of Chemical Research,2021,54(18):3550-3562.
[32] HUANG Q H,YANG T H,SONG Y P,et al.A three-dimensional(3D)liver-kidney on a chip with a biomimicking circulating system for drug safety evaluation[J].Lab on a Chip,2024,24(6):1715-1726.
[33] KURNIAWAN D A,LEO S,INAMATSU M,et al.Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism[J].PNAS Nexus,2024,3(2):pgae070.
[34] RONALDSON-BOUCHARD K,TELES D,YEAGER K,et al.A multi-organ chip with matured tissue niches linked by vascular flow[J].Nature Biomedical Engineering,2022,6(4):351-371.
[35] WANG P,JIN L,ZHANG M,et al.Blood-brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung-brain microphysiological system[J].Nature Biomedical Engineering,2024,8(8):1053-1068.
[36] ECKSTRUM K,STRIZ A,FERGUSON M,et al.Evaluation of the utility of the Beta Human Liver Emulation System(BHLES)for CFSAN's regulatory toxicology program[J].Food and Chemical Toxicology,2022,161:112828.
[37] PIRES DE MELLO C P,CARMONA-MORAN C,MCALEER C W,et al.Microphysiological heart-liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery[J].Lab on a Chip,2020,20(4):749-759.
[38] 李兆钰,丁书文,马度芳,等.基于心系疾病热毒学说探讨中医药抗炎治疗动脉粥样硬化[J].中华中医药杂志,2021,36(7):3916-3920.
[39] 王栋,于雪,黄凯,等.清热解毒中药调节炎症反应对心血管疾病异病同治的意义[J].中国中药杂志,2022,47(20):5418-5423.
[40] GAO Z,DU Z Y,HOU Y,et al.A microfluidic coculture model for mapping signaling perturbations and precise drug screening against macrophage-mediated dynamic myocardial injury[J].Acta Pharmaceutica Sinica:B,2024,14(12):5393-5406.
[41] CHEN P,ZHANG J,WANG C,et al.The pathogenesis and treatment mechanism of Parkinson's disease from the perspective of traditional Chinese medicine[J].Phytomedicine,2022,100:154044.
[42] 孙雪,何建成,杨帅.何建成教授分期治疗帕金森病痴呆的经验[J].中华中医药学刊,2023,41(5):127-130.
[43] TRAPECAR M,WOGRAM E,SVOBODA D,et al.Human physiomimetic model integrating microphysiological systems of the gut,liver,and brain for studies of neurodegenerative diseases[J].Science Advances,2021,7(5):eabd1707.
[44] NGUYEN V V T,YE S C,GKOUZIOTI V,et al.A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles[J].Journal of Extracellular Vesicles,2022,11(11):12280.
[45] SHI Y W,HE X L,WANG H,et al.Construction of a novel blood brain barrier-glioma microfluidic chip model:applications in the evaluation of permeability and anti-glioma activity of traditional Chinese medicine components[J].Talanta,2023,253:123971.
[46] FAN F F,XU N,SUN Y C,et al.Uncovering the metabolic mechanism of salidroside alleviating microglial hypoxia inflammation based on microfluidic chip-mass spectrometry[J].Journal of Proteome Research,2022,21(4):921-929.
[47] ZHANG H Y,HUANG H M,SONG H,et al.Serum metabolomics reveals the intervention mechanism and compatible regularity of Chaihu Shu Gan San on chronic unpredictable mild stress-induced depression rat model[J].Journal of Pharmacy and Pharmacology,2020,72(8):1133-1143.
[48] 马骏,曼琼,邓毅,等.代谢组学在中药七情配伍中的应用研究进展[J].中草药,2020,51(1):276-280.
[49] 张凯,任献青,霍桢毅,等.基于气味配伍理论辨治儿童血尿[J].中国中医基础医学杂志,2020,26(7):884-886.
[50] 王一婷,冯全生,刘文平,等.《脾胃论》“苦甘”配伍思想发微[J].中华中医药杂志,2022,37(8):4610-4613.
[51] LV S,WANG Q,ZHANG X L,et al.Mechanisms of multi-omics and network pharmacology to explain traditional Chinese medicine for vascular cognitive impairment:a narrative review[J].Phytomedicine,2024,123:155231.
[52] LU Z H,YUAN Y,HAN Q,et al.Lab-on-a-chip:an advanced technology for the modernization of traditional Chinese medicine[J].Chinese Medicine,2024,19(1):80.
[53] MILANI N,PARROTT N,ORTIZ FRANYUTI D,et al.Application of a gut-liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil[J].Lab on a Chip,2022,22(15):2853-2868.
[54] CHEN Y Y,LU Y T,WANG Y D,et al.Xiaoyaosan improves depression-like behaviours in mice with post-stroke depression by modulating gut microbiota and microbial metabolism and regulating P2X7R/NLRP3 inflammasome[J].Phytomedicine,2025,145:157078.
(收稿日期:2025-11-18)

备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(82474342)
中国青年人才托举工程(2024-QNRC2-B18)
全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号)
江苏省中医药科技发展计划重点项目(ZD202202)
江苏省中医院院级创新发展基金项目(Y2023CX25)
△通信作者 E-mail:wenge1977@126.com
更新日期/Last Update: 2026-07-15