[1]张万义 王笑青 罗姣 侯宏理 孔西建 刘玉珂 吴丹 王咪娜 范鑫梅.骨松益骨方加减对肾虚血瘀型绝经后骨质疏松症患者骨代谢与脂代谢的影响[J].中国中医骨伤科杂志,2026,34(05):45-50.[doi:10.20085/j.cnki.issn1005-0205.260507]
　ZHANG Wanyi,WANG Xiaoqing,LUO Jiao,et al.A Study on the Effects and Correlation between the Modified Gusong Yigu Formula and Bone Metabolism and Lipid Metabolism in Postmenopausal Osteoporosis Patients with Kidney Deficiency and Blood Stasis Syndrome[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2026,34(05):45-50.[doi:10.20085/j.cnki.issn1005-0205.260507]
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骨松益骨方加减对肾虚血瘀型绝经后骨质疏松症患者骨代谢与脂代谢的影响()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第34卷
期数:
2026年05期
页码:
45-50
栏目:
临床研究
出版日期:
2026-05-10

文章信息/Info

Title:
A Study on the Effects and Correlation between the Modified Gusong Yigu Formula and Bone Metabolism and Lipid Metabolism in Postmenopausal Osteoporosis Patients with Kidney Deficiency and Blood Stasis Syndrome
文章编号:
1005-0205(2026)05-0045-06
作者:
张万义 王笑青 罗姣 侯宏理 孔西建 刘玉珂 吴丹 王咪娜 范鑫梅
1河南省洛阳正骨医院(河南省骨科医院)(河南 洛阳,471002)
Author(s):
ZHANG Wanyi1; WANG Xiaoqing1△; LUO Jiao1; HOU Hongli1; KONG Xijian1; LIU Yuke1; WU Dan1; WANG Mina1; FAN Xinmei1
1Luoyang Orthopedic-Traumatological Hospital of Henan Province(Henan Provincial Orthopedic Hospital),Luoyang 471002,Henan China.
关键词:
骨松益骨方;  骨质疏松症;  肾虚血瘀型;  骨代谢指标;  脂代谢指标
Keywords:
Gusong Yigu formula;  osteoporosis;  kidney deficiency and blood stasis type;  bone metabolism indicators;  lipid metabolism indicators
分类号:
R274
DOI:
10.20085/j.cnki.issn1005-0205.260507
文献标志码:
A
摘要:
目的:探讨骨松益骨方加减治疗肾虚血瘀型绝经后骨质疏松症的疗效,观察其对患者骨代谢与脂代谢指标的影响,并分析骨代谢与脂代谢之间的相关性。方法:选取2024年1月至2025年5月就诊的肾虚血瘀型绝经后骨质疏松症患者70例为研究对象,采用随机数字表法将70例患者分为观察组和对照组,其中观察组38例,对照组32例。对照组给予碳酸钙D3片+骨化三醇软胶囊+利塞膦酸钠片治疗,观察组在对照组基础上加用骨松益骨方加减治疗,连续治疗3个月,分别于治疗前和治疗结束后,检测β-胶原特殊序列(β-CTX)、骨钙素N端中分子片断(N-MID)及总Ⅰ型胶原氨基酸延长肽(PINP),同时检测脂代谢指标甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),并计算动脉粥样硬化指数(AI=(TC-HDL)/HDL),同时分析骨代谢及脂代谢指标之间的相关性。结果:治疗3个月后,两组患者的β-CTX、N-MID及PINP水平均较治疗前明显改善,差异有统计学意义(P<0.05); 对照组治疗前后TG、TC、HDL-C、LDL-C及AI值的差异均无统计学意义(P>0.05); 观察组治疗3个月后,各脂代谢指标较治疗前明显改善,差异有统计学意义(P<0.05)。两组组间比较,治疗3个月后,观察组的N-MID、PINP水平高于对照组,差异有统计学意义(P<0.05),β-CTX水平低于对照组,差异有统计学意义(P<0.05); 观察组在降低TG、TC、LDL-C水平及AI值方面均优于对照组,差异有统计学意义(P<0.05)。骨代谢指标与脂代谢指标的相关性分析结果显示:血清N-MID、PINP与TG、TC、LDL-C及AI值负相关,差异有统计学意义(P<0.05),与HDL-C正相关,差异有统计学意义(P<0.05)。β-CTX与TG、TC、LDL-C及AI值正相关,差异有统计学意义(P<0.05),与HDL-C无显著相关性,差异无统计学意义(P>0.05)。结论:骨松益骨方加减能够有效改善肾虚血瘀型绝经后骨质疏松症患者的骨代谢相关指标,同时能够调节脂代谢紊乱,表现为降低TG、TC、LDL-C水平及AI值,升高HDL-C水平。证实骨代谢与脂代谢指标间存在显著相关性,提示纠正脂代谢紊乱可能有助于改善骨代谢。
Abstract:
Objective:To observe the effects of modified Gusong Yigu formula on bone metabolism and lipid metabolism in postmenopausal osteoporosis patients with kidney deficiency and blood stasis,and further explore the correlation between bone metabolism and lipid metabolism.Methods:Seventy patients with postmenopausal osteoporosis of kidney deficiency and blood stasis pattern,treated from January 2024 to May 2025 were selected.The 70 patients were randomly divided into the observation group and the control group using the random number table method,with 38 cases in the observation group and 32 cases in the control group.The control group was treated with calcium carbonate D3 tablets,calcitriol soft capsules,and risedronic acid sodium tablets.On the basis of the control group,the observation group was treated with Gusong Yigu formula.The treatment lasted for 3 months.Before and after the treatment,the changes in bone metabolism indicators,such as β-C-terminal telopeptide of type Ⅰ collagen(β-CTX),N-terminal propeptide of type Ⅰ procollagen(N-MID),and total Ⅰ-type collagen amino-terminal propeptide(PINP),and lipid metabolism indicators,such as triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C),as well as atherosclerosis index [AI=(TC-HDL)/HDL] were observed.At the same time,the correlation between bone metabolism markers and lipid metabolism indicators was analyzed.Results:After 3 months of treatment,both groups showed significant improvements in the β-CTX,N-MID,and PINP compared to before treatment(P<0.05); there was no statistical significance in the improvement of TG,TC,HDL-C,LDL-C,and AI between the two groups before and after treatment(P>0.05); after 3 months of treatment,the lipid metabolism indicators in the observation group showed statistically significant improvements compared to baseline(P<0.05). When comparing the two groups,the levels of N-MID and PINP in the observation group were higher than those in the control group after 3 months of treatment(P<0.05),while the level of β-CTX was lower than that in the control group(P<0.05); the observation group showed better improvement in lipid metabolism indicators(including TG,TC,and LDL-C)compared with the control group(P<0.05),and also showed better improvement in the AI(P<0.05).Correlation analysis of bone metabolism indicators and lipid metabolism indicators:serum osteocalcin,PINP were negatively correlated with TG,TC,LDL-C,and AI(P<0.05),and positively correlated with HDL-C(P<0.05).β-CTX was positively correlated with TG,TC,LDL-C,and AI(P<0.05),but showed no correlation with HDL-C(P>0.05).Conclusion:The modified Gusong Yigu formula can improve the bone metabolism-related indicators in postmenopausal osteoporosis patients with kidney deficiency and blood stasis syndrome; at the same time,it can regulate the lipid metabolism of patients,reduce TC,TG and LDL-C levels,and increase HDL-C levels.Moreover,there is a significant correlation between bone metabolism and lipid metabolism.Improving lipid metabolism may therefore promote the improvement in bone metabolism.

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(收稿日期:2025-10-13)

备注/Memo

备注/Memo:
基金项目:河南省科技攻关项目(232102310124)
河南省中医药科研专项课题(2025ZY3097)
△通信作者 E-mail:lyzgwxq@163.com
更新日期/Last Update: 2026-05-15