参考文献/References:
[1] XIE Y L,SU N,YANG J,et al.FGF/FGFR signaling in health and disease[J].Signal Transduction and Targeted Therapy,2020,5:181.
[2] KOMMALAPATI A,TELLA S H,BORAD M,et al.FGFR inhibitors in oncology:insight on the management of toxicities in clinical practice[J].Cancers,2021,13(12):2968.
[3] CUI X Y,SUN Q H,WANG H Q.Targeting fibroblast growth factor(FGF)-21:a promising strategy for metabolic dysfunction-associated steatotic liver disease treatment[J].Frontiers in Pharmacology,2025,16:1510322.
[4] AALDIJK A S,VERZIJL C R C,JONKER J W,et al.Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta Klotho[J].Frontiers in Endocrinology,2023,14:1150222.
[5] KATOH M.Fibroblast growth factor receptors as treatment targets in clinical oncology[J].Nature Reviews Clinical Oncology,2019,16(2):105-122.
[6] MOOSA S,WOLLNIK B.Altered FGF signalling in congenital craniofacial and skeletal disorders[J].Seminars in Cell & Developmental Biology,2016,53:115-125.
[7] LI H Z,ZHANG J L,YUAN D L,et al.Role of signaling pathways in age-related orthopedic diseases:focus on the fibroblast growth factor family[J].Military Medical Research,2024,11(1):40.
[8] LIU Y,DA W,XU M J,et al.Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis[J].Signal Transduction and Targeted Therapy,2025,10:40.
[9] JOSEPH R,BOATENG A,SRIVASTAVA O P,et al.Role of fibroblast growth factor receptor 2(FGFR2)in corneal stromal thinning[J].Investigative Ophthalmology & Visual Science,2023,64(12):40.
[10] XIE Y L,ZINKLE A,CHEN L,et al.Fibroblast growth factor signalling in osteoarthritis and cartilage repair[J].Nature Reviews Rheumatology,2020,16(10):547-564.
[11] MCCLURG O,TINSON R,TROEBERG L.Targeting cartilage degradation in osteoarthritis[J].Pharmaceuticals,2021,14(2):126.
[12] XU L,WU Y X,XIONG Z M,et al.Mesenchymal stem cells reshape and provoke proliferation of articular chondrocytes by paracrine secretion[J].Scientific Reports,2016,6:32705.
[13] LI Y X,SHU J,KOU N N,et al.FGF1 reduces cartilage injury in osteoarthritis via regulating AMPK/Nrf2 pathway[J].Journal of Molecular Histology,2023,54(5):427-438.
[14] ZHAO Y P,LI Y H,QU R Z,et al.Cortistatin binds to TNF-α receptors and protects against osteoarthritis[J].EBioMedicine,2019,41:556-570.
[15] NA H S,PARK J S,CHO K H,et al.Interleukin-1-interleukin-17 signaling axis induces cartilage destruction and promotes experimental osteoarthritis[J].Frontiers in Immunology,2020,11:730.
[16] HUANG H C,XIE J,WEI J Y,et al.Fibroblast growth factor 8(FGF8)up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65[J].Journal of Bone and Mineral Metabolism,2023,41(1):17-28.
[17] XIE M,LI J P.Heparan sulfate proteoglycan-A common receptor for diverse cytokines[J].Cellular Signalling,2019,54:115-121.
[18] NAGATA K,HOJO H,CHANG S H,et al.Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development[J].Nature Communications,2022,13:6187.
[19] ELLMAN M B,YAN D,AHMADINIA K,et al.Fibroblast growth factor control of cartilage homeostasis[J].Journal of Cellular Biochemistry,2013,114(4):735-742.
[20] YAO Q,WU X H,TAO C,et al.Osteoarthritis:pathogenic signaling pathways and therapeutic targets[J].Signal Transduction and Targeted Therapy,2023,8:56.
[21] CHANDEL A S,STOCKER M,ÖZBUDAK E M.The role of fibroblast growth factor signaling in somitogenesis[J].DNA and Cell Biology,2023,42(10):580-584.
[22] WANG L P,ROTH T,ABBOTT M,et al.Osteoblast-derived FGF9 regulates skeletal homeostasis[J].Bone,2017,98:18-25.
[23] ZHOU S,WANG Z,TANG J,et al.Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis[J].Osteoarthritis and Cartilage,2016,24(12):2181-2192.
[24] JIANG P,DOU X X,LI S G,et al.miR-590-5p affects chondrocyte proliferation,apoptosis,and inflammation by targeting FGF18 in osteoarthritis[J].American Journal of Translational Research,2021,13(8):8728-8741.
[25] MÜLLER S,LINDEMANN S,GIGOUT A.Effects of sprifermin,IGF1,IGF2,BMP7,or CNP on bovine chondrocytes in monolayer and 3D culture[J].Journal of Orthopaedic Research,2020,38(3):653-662.
[26] KUANG L,WU J Y,SU N,et al.FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice[J].Annals of the Rheumatic Diseases,2020,79(1):112-122.
[27] RAMEZANPOUR S,KANTHAWANG T,LYNCH J,et al.Impact of sustained synovitis on knee joint structural degeneration:4-year MRI data from the osteoarthritis initiative[J].Journal of Magnetic Resonance Imaging,2023,57(1):153-164.
[28] LI R,WANG B,HE C Q,et al.Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis[J].Genetics and Molecular Research,2015,14(3):11191-11199.
[29] PEI M,HE F,VUNJAK-NOVAKOVIC G.Synovium-derived stem cell-based chondrogenesis[J].Differentiation,2008,76(10):1044-1056.
[30] GOSHIMA A,ETANI Y,HIRAO M,et al.Basic fibroblast growth factor promotes meniscus regeneration through the cultivation of synovial mesenchymal stem cells via the CXCL6-CXCR2 pathway[J].Osteoarthritis and Cartilage,2023,31(12):1581-1593.
[31] KAWATA K,KOGA H,TSUJI K,et al.Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci[J].Stem Cell Research & Therapy,2021,12(1):414.
[32] YANG L L,CHEN Z R,GUO H H,et al.Extensive cytokine analysis in synovial fluid of osteoarthritis patients[J].Cytokine,2021,143:155546.
[33] HU S L,THADEVOOS L A,HO T L,et al.FGF23 facilitates IL-1β synthesis in rheumatoid arthritis through activating PI3K,Akt,and NF-κB pathways[J].Environmental Toxicology,2024,39(6):3283-3291.
[34] MATSUMURA E,TSUJI K,KOMORI K,et al.Pretreatment with IL-1β enhances proliferation and chondrogenic potential of synovium-derived mesenchymal stem cells[J].Cytotherapy,2017,19(2):181-193.
[35] CHEN Y,HU Y Z,YU Y E,et al.Subchondral trabecular rod loss and plate thickening in the development of osteoarthritis[J].Journal of Bone and Mineral Research,2018,33(2):316-327.
[36] YANG W Y,CAO Y T,ZHANG Z,et al.Targeted delivery of FGF2 to subchondral bone enhanced the repair of articular cartilage defect[J].Acta Biomaterialia,2018,69:170-182.
[37] KUBOTA K,ISEKI S,KURODA S,et al.Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2[J].Bone,2002,31(4):465-471.
[38] KARUPPAIAH K,YU K,LIM J,et al.FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth[J].Development,2016,143(10):1811-1822.
[39] AMIZUKA N,DAVIDSON D,LIU H L,et al.Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development[J].Bone,2004,34(1):13-25.
[40] LEE C J,MOON S J,JEONG J H,et al.Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis[J].Cell Death & Disease,2018,9:401.
[41] HARADA M,AKITA K.Mouse fibroblast growth factor 9 N143T mutation leads to wide chondrogenic condensation of long bones[J].Histochemistry and Cell Biology,2020,153(4):215-223.
[42] LIU Z H,XU J S,COLVIN J S,et al.Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18[J].Genes & Development,2002,16(7):859-869.
[43] ZHAI F,SONG N,MA J S,et al.FGF18 inhibits MC3T3-E1 cell osteogenic differentiation via the ERK signaling pathway[J].Molecular Medicine Reports,2017,16(4):4127-4132.
(收稿日期:2025-08-30)