[1]宋婷,宋敏,胡康一,等.成纤维细胞生长因子在骨关节炎病程中的调控作用及研究进展[J].中国中医骨伤科杂志,2026,34(04):106-112.[doi:10.20085/j.cnki.issn1005-0205.260418]
 SONG Ting,SONG Min,HU Kangyi,et al.Research Progress on the Mechanism of Fibroblast Growth Factor Regulating Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2026,34(04):106-112.[doi:10.20085/j.cnki.issn1005-0205.260418]
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成纤维细胞生长因子在骨关节炎病程中的调控作用及研究进展()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第34卷
期数:
2026年04期
页码:
106-112
栏目:
文献综述
出版日期:
2026-04-10

文章信息/Info

Title:
Research Progress on the Mechanism of Fibroblast Growth Factor Regulating Osteoarthritis
文章编号:
1005-0205(2026)04-0106-07
作者:
宋婷1宋敏12胡康一1贾筱1宋永嘉12△
1甘肃中医药大学(兰州,730000)
2甘肃中医药大学附属医院
Author(s):
SONG Ting1SONG Min12HU Kangyi1JIA Xiao1SONG Yongjia12△
1Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China; 2The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China.
关键词:
成纤维细胞生长因子 骨关节炎 软骨病变 滑膜炎症 软骨下骨硬化
Keywords:
fibroblast growth factor osteoarthritis cartilage lesions synovial inflammation subchondral bone sclerosis
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.260418
文献标志码:
A
摘要:
骨关节炎是一种常见的慢性退行性疾病,主要表现为关节软骨退变、软骨下骨硬化、滑膜炎症和关节功能障碍。近年来,成纤维细胞生长因子家族作为一类多功能蛋白,其成员及其受体通过调节软骨修复、炎症反应、破骨和成骨等过程影响骨关节炎发生发展。系统梳理了成纤维细胞生长因子在骨关节炎中的调控机制,重点分析了成纤维细胞生长因子信号如何影响软骨细胞增殖、分化、软骨基质降解、软骨下骨的硬化,探讨了成纤维细胞生长因子信号在软骨退化和修复过程中的双向调控作用。在此基础上,进一步详细总结了成纤维细胞生长因子信号调控骨关节炎病程中滑膜炎症的作用机制,并探讨了基于成纤维细胞生长因子调控的骨关节炎治疗新方向。
Abstract:
Osteoarthritis(OA)is a common chronic degenerative joint disease characterized by articular cartilage degeneration,subchondral bone sclerosis,synovial inflammation,and joint dysfunction.In recent years,the fibroblast growth factor(FGF)family-a group of multifunctional proteins-has been shown to influence the pathogenesis and progression of OA by regulating processes such as cartilage repair,inflammatory responses,osteoclastogenesis,and osteogenesis via FGFs and their receptors.This review systematically summarizes the regulatory mechanisms of FGF in OA,with a focus on how FGF signaling affects chondrocyte proliferation,differentiation,cartilage matrix degradation,and subchondral bone sclerosis.It further explores the bidirectional regulatory role of FGF signaling in cartilage degeneration and repair.Building on this foundation,the article provides a detailed summary of the mechanisms by which FGF signaling modulates synovial inflammation during OA progression and discusses novel therapeutic strategies for OA based on FGF regulation.

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(收稿日期:2025-08-30)

备注/Memo

备注/Memo:
基金项目:2024年甘肃省高校教师创新基金项目(2024A-087)
2023年度甘肃中医药大学成果转化培育项目(2023CGZH-1)
2025年度甘肃中医药大学研究生“创新创业基金”项目(2025CXCY-013,2025CXCY-014)
通信作者 E-mail:syj@gszy.edu.cn
更新日期/Last Update: 2026-04-15