[1]鲁俊山,房彩平,高竟,等.牛膝温经汤治疗寒湿痹阻型膝骨关节炎的临床研究[J].中国中医骨伤科杂志,2026,34(02):58-63.[doi:10.20085/j.cnki.issn1005-0205.260209]
　LU Junshan,FANG Caiping,GAO Jing,et al.Clinical Study on Niuxi Wenjing Decoction in the Treatment of Knee Osteoarthritis with Cold-Dampness Obstruction Syndrome[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2026,34(02):58-63.[doi:10.20085/j.cnki.issn1005-0205.260209]
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牛膝温经汤治疗寒湿痹阻型膝骨关节炎的临床研究()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第34卷
期数:
2026年02期
页码:
58-63
栏目:
临床研究
出版日期:
2026-02-15

文章信息/Info

Title:
Clinical Study on Niuxi Wenjing Decoction in the Treatment of Knee Osteoarthritis with Cold-Dampness Obstruction Syndrome
文章编号:
1005-0205(2026)02-0058-06
作者:
鲁俊山1; 房彩平1; 高竟1; 陶帅1△
1泰州市中医院(江苏 泰州,225300)
Author(s):
LU Junshan1; FANG Caiping1; GAO Jing1; TAO Shuai1△
1Taizhou Hospital of Traditional Chinese Medicine,Taizhou 225300,Jiangsu China.
关键词:
膝骨关节炎;  牛膝温经汤;  寒湿痹阻
Keywords:
knee osteoarthritis;  Niuxi Wenjing decoction;  cold-dampness obstruction
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.260209
文献标志码:
A
摘要:
目的:探讨牛膝温经汤治疗寒湿痹阻型膝骨关节炎的临床疗效。方法:选取80例寒湿痹阻型膝骨关节炎患者,通过随机数字表法分为观察组和对照组(各40例)。对照组口服塞来昔布胶囊,0.2 g/次,2次/d; 观察组口服牛膝温经汤,1剂/d,分2次温服。4周后观察两组患者VAS评分、中医证候评分、WOMAC评分、肌骨超声下滑膜评价及血清炎症因子IL-1β、TNF-α治疗后的变化。结果:两组患者各观察指标治疗前比较,差异无统计学意义(P>0.05); 治疗后各观察指标评分较其治疗前明显降低,差异有统计学意义(P<0.01); 治疗后与对照组比较,观察组患者中医证候评分及WOMAC评分下降,差异有统计学意义(P<0.01)。结论:牛膝温经汤治疗寒湿痹阻型膝骨关节炎疗效满意,其机制可能与炎症因子IL-1β、TNF-α的降低有关。
Abstract:
Objective:To discuss the clinical efficacy of Niuxi Wenjing decoction in the treatment of knee osteoarthritis(KOA)with cold-dampness obstruction syndrome.Methods:Eighty patients with KOA and cold-dampness obstruction were randomly divided into observation group and control group with 40 cases in each group by using random number table method.The control group received oral celecoxib capsules,0.2 g each times,twice daily,whereas the observation group was given oral Niuxi Wenjing decoction,1 dose per day,taken warmly twice a day.Both treatments were given for 4 weeks.The changes in VAS scores,TCM symptom scores,WOMAC scores,musculoskeletal ultrasound assessments,and serum levels of IL-1β and TNF-α were observed before and after treatment.Results:No statistically significant differences were observed in any of observation indicators between the two groups before treatment(P>0.05).After treatment,significant decreases were found in all observation indicators within each group compared to their respective baseline levels(P<0.01).Compared with the control group,the observation group showed lower scores after treatment for both TCM syndrome assessment and WOMAC scores(P<0.01).Conclusion:Niuxi Wenjing decoction shows significant efficacy in the treatment of KOA with cold-dampness obstruction.The mechanism may be associated with the reduction of inflammatory factors(IL-1β,TNF-α).

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(收稿日期:2025-06-29)

备注/Memo

备注/Memo:
基金项目:江苏省中医药科技发展计划面上项目(MS2023149)
泰州市大健康产业创新能力提升(社会发展)非企项目(TS202313)
泰州市中医药科技项目(TZ202306)
△通信作者 E-mail:taoshuai130@163.com
更新日期/Last Update: 2026-02-15