[1]刘明明 李洪叶 冯骁骁 程建△.巨首相关蛋白-1对肝肾亏虚型糖尿病性骨质疏松症的影响研究[J].中国中医骨伤科杂志,2025,33(09):17-21.[doi:10.20085/j.cnki.issn1005-0205.250903]
　LIU Mingming LI Hongye FENG Xiaoxiao CHENG Jian.Study on the Role of Potential Targets in Liver and Kidney Deficiency Type Diabetic Osteoporosis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(09):17-21.[doi:10.20085/j.cnki.issn1005-0205.250903]
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巨首相关蛋白-1对肝肾亏虚型糖尿病性骨质疏松症的影响研究()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年09期
页码:
17-21
栏目:
临床研究
出版日期:
2025-09-15

文章信息/Info

Title:
Study on the Role of Potential Targets in Liver and Kidney Deficiency Type Diabetic Osteoporosis
文章编号:
1005-0205(2025)09-0017-05
作者:
刘明明1; 2 李洪叶1; 2 冯骁骁1; 2 程建3△
1徐州医科大学连云港临床学院(连云港市第二人民医院)(江苏 连云港,222000)
2南京医学大学康达学院附属连云港市第二人民医院
3徐州市中心医院
Author(s):
LIU Mingming1; 2 LI Hongye1; 2 FENG Xiaoxiao1; 2 CHENG Jian3△
1Affiliated Lianyungang Clinical College of Xuzhou Medical University(The Second People's Hospital of Lianyungang),Lianyungang 222000,Jiangsu China; 2The Second People's Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical University,Lianyungang 222000,Jiangsu China; 3Xuzhou Central Hospital,Xuzhou 221000,Jiangsu China.
关键词:
糖尿病性骨质疏松症;  加味六味地黄汤;  巨首相关蛋白-1;  肝肾亏虚型;  中医证候
Keywords:
diabetic osteoporosis;  Jiawei Liuwei Dihuang decoction;  Dickkopf-related protein 1;  liver-kidney deficiency;  Chinese medicine evidence and symptoms
分类号:
R68
DOI:
10.20085/j.cnki.issn1005-0205.250903
文献标志码:
A
摘要:
目的:探索肝肾亏虚型糖尿病性骨质疏松症的潜在靶点,研究巨首相关蛋白-1(DKK1)与肝肾亏虚型糖尿病性骨质疏松症的相关性及加味六味地黄汤的治疗作用。方法:收集符合纳入标准的糖尿病性骨质疏松症患者及健康受试者,其中糖尿病性骨质疏松症患者根据是否接受加味六味地黄汤治疗分为观察组和对照组(各30例),健康受试者为空白组(20例),并评估各组的巨首相关蛋白-1表达水平、中医证候疗效评分、骨密度、疼痛视觉模拟量表(VAS)评分、36条健康调查简表(SF-36)评分和药物不良反应。结果:健康受试者的巨首相关蛋白-1水平明显低于糖尿病性骨质疏松症患者(P<0.05),经过加味六味地黄汤治疗后,观察组的巨首相关蛋白-1水平较对照组显著降低(P<0.05),并且观察组的骨密度、VAS评分、SF-36评分和中医证候指标评分均优于对照组(P<0.05)。结论:巨首相关蛋白-1的表达与肝肾亏虚型糖尿病性骨质疏松症密切相关,其可能是肝肾亏虚型糖尿病性骨质疏松症的潜在靶点; 加味六味地黄汤可降低患者巨首相关蛋白-1的表达,改善中医证候,缓解疼痛并提高生活质量。
Abstract:
Objective:To explore therapeutic potential targets for liver-kidney deficiency type diabetic osteoporosis and to investigate the role of Dickkopf-related protein 1(DKK1)in the treatment of diabetic osteoporosis with the addition of Jiawei Liuwei Dihuang decoction.Methods:Patients with diabetic osteoporosis and healthy subjects who met the inclusion criteria were collected,in which patients with diabetic osteoporosis evidence were divided into observation group(n=30)and control group(n=30)according to whether or not they used to receive the treatment of Jiawei Liuwei Dihuang decoction,and the healthy subjects were the blank group(n=20).The DKK1 level,the efficacy of the Chinese medicine evidence,the bone mineral density,visual analogue scale(VAS)scores,the Short Form of the 36-item Health Survey(SF-36)scores and adverse drug reactions were evaluated and compared among the groups.Results:The DKK1 level of the blank group was significantly lower than that of patients with diabetic osteoporosis(P<0.05),and the VAS and SF-36 scores and TCM evidence indicators of the blank group were better than those of patients with diabetic osteoporosis(P<0.05).In addition,the DKK1 level of the observation group was significantly lower than that of the control group after the treatment with Jiawei Liuwei Dihuang decoction(P<0.05),and the bone mineral density,VAS and SF-36 scores,and Chinese medicine evidence indexes of the observation group were all better than those of the control group(P<0.05).Conclusion:DKK1 expression is closely related to liver-kidney deficiency type diabetic osteoporosis and may serve as a potential therapeutic target.In addition,Jiawei Liuwei Dihuang decoction can effectively reduce the expression of DKK1 in patients with liver-kidney deficiency type diabetic osteoporosis,improve the symptoms of traditional Chinese medicine,relieve pain and improve the quality of life.

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(收稿日期:2025-02-02)

备注/Memo

备注/Memo:
基金项目:江苏省卫生健康委医学科研项目(H2023049)
连云港市中医药科技发展计划项目(ZD202210)
徐州市科技局基础研究计划项目(KC22037)
△通信作者 E-mail:drchengjian@126.com
更新日期/Last Update: 2025-09-15