[1]游沛杰,龚冠亦,刘锦涛△.“骨-脑轴”在中枢神经系统与骨骼代谢双向调节中的作用及其研究进展[J].中国中医骨伤科杂志,2025,33(06):91-96.[doi:10.20085/j.cnki.issn1005-0205.250616]
 YOU Peijie,GONG Guanyi,LIU Jintao.The Role of the “Bone Brain Axis” in the Bidirectional Regulation of Central Nervous System and Bone Metabolism and Its Research Progress[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(06):91-96.[doi:10.20085/j.cnki.issn1005-0205.250616]
点击复制

“骨-脑轴”在中枢神经系统与骨骼代谢双向调节中的作用及其研究进展()
分享到:

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年06期
页码:
91-96
栏目:
文献综述
出版日期:
2025-06-15

文章信息/Info

Title:
The Role of the “Bone Brain Axis” in the Bidirectional Regulation of Central Nervous System and Bone Metabolism and Its Research Progress
文章编号:
1005-0205(2025)06-0091-06
作者:
游沛杰1龚冠亦2刘锦涛2△
1南京中医药大学(南京,210023) 2南京中医药大学附属苏州市中医医院
Author(s):
YOU Peijie1GONG Guanyi2LIU Jintao2△
1Nanjing University of Chinese Medicine,Nanjing 210023,China; 2Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou 215001,Jiangsu China.
关键词:
骨-脑轴 骨代谢 神经系统 骨源性分子
Keywords:
bone brain axis bone metabolism nervous system bone derived molecules
分类号:
R681
DOI:
10.20085/j.cnki.issn1005-0205.250616
文献标志码:
A
摘要:
骨-脑轴作为近年来备受关注的前沿研究领域,其生理与病理机制的研究取得了显著进展,揭示了骨骼代谢系统与中枢神经系统之间的双向调节机制。然而在神经系统疾病和骨骼疾病的关联及治疗方面,骨-脑轴的研究仍存在不足。基于此,本文首先总结了骨-脑轴的生理与病理机制,探讨了骨骼通过释放骨源性分子调节大脑功能的机制,以及中枢神经系统通过交感神经系统、神经递质及神经-内分泌轴对骨代谢的调控作用。在此基础上,本文进一步详细总结了骨代谢疾病(如骨质疏松)与神经退行性疾病(如帕金森病、痴呆和癫痫)之间的关联,并探讨了靶向骨源性因子及炎症因子在治疗骨骼与神经系统疾病中的应用前景。
Abstract:
As a frontier research field that has attracted much attention in recent years,the research on the physiological and pathological mechanisms of bone brain axis has made significant progress,revealing the bidirectional regulation mechanism between the bone metabolic system and the central nervous system.However,there are still deficiencies in the study of bone brain axis in the association and treatment of neurological and skeletal diseases.Based on this,this paper first summarizes the physiological and pathological mechanisms of bone brain axis,discusses the mechanism of bone regulating brain function by releasing bone derived molecules,and the regulation of bone metabolism by the central nervous system through sympathetic nervous system,neurotransmitters and neuroendocrine axis.On this basis,this paper further summarizes the association between bone metabolic diseases(such as osteoporosis)and neurodegenerative diseases(such as Parkinson's disease,dementia and epilepsy),and discusses the application prospect of targeting bone derived factors and inflammatory factors in the treatment of bone and nervous system diseases.

参考文献/References:

[1] KARSENTY G,FERRON M.The contribution of bone to whole-organism physiology[J].Nature,2012,481(7381):314-320.
[2] WU J,DOU Y,LIU W,et al.Osteocalcin improves outcome after acute ischemic stroke[J].Aging(Albany NY),2020,12(1):387-396.
[3] BERGER J M,SINGH P,KHRIMIAN L,et al.Mediation of the acute stress response by the skeleton[J].Cell Metab,2019,30(5):890-902.
[4] SHI T,SHEN S,SHI Y,et al.Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression[J].Nat Metab,2024,6(3):531-549.
[5] 徐伟丽,牛玲玲,王文侠,等.经典Wnt信号通路对骨代谢的调节作用[J].中国骨质疏松杂志,2016,22(3):376-380.
[6] RICHTER B,FAUL C.FGF23 actions on target tissues-with and without klotho[J].Front Endocrinol(Lausanne),2018,9:189.
[7] YANG S,WAGSTYL K,MENG Y,et al.Cortical patterning of morphometric similarity gradient reveals diverged hierarchical organization in sensory-motor cortices[J].Cell Rep,2021,36(8):109582.
[8] ZHANG Y,CHEN C Y,LIU Y W,et al.Neuronal induction of bone-fat imbalance through osteocyte neuropeptide Y[J].Adv Sci(Weinh),2021,8(24):e2100808.
[9] TAKAKURA A,LEE J W,HIRANO K,et al.Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats[J].Bone Res,2017,5:17002.
[10] CHEN F,OUYANG Y,YE T,et al.Estrogen inhibits RANKL-induced osteoclastic differentiation by increasing the expression of TRPV5 channel[J].J Cell Biochem,2014,115(4):651-658.
[11] WANG Y,NISHIDA S,ELALIEH H Z,et al.Role of IGF-1 signaling in regulating osteoclastogenesis[J].J Bone Miner Res,2006,21(9):1350-1358.
[12] BEIER E E,SHEU T J,RESSEGUIE E A,et al.Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice[J].Bone Res,2017,5:17013.
[13] CORNISH J,CALLON K E,BAVA U,et al.Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo[J].J Endocrinol,2002,175(2):405-415.
[14] YANG C H,ANN-ONDA D,LIN X,et al.Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes[J].Mol Metab,2022,55:101413.
[15] ELEFTERIOU F,AHN J D,TAKEDA S,et al.Leptin regulation of bone resorption by the sympathetic nervous system and CART[J].Nature,2005,434(7032):514-520.
[16] BALDOCK P A,LIN S,ZHANG L,et al.Neuropeptide Y attenuates stress-induced bone loss through suppression of noradrenaline circuits[J].J Bone Miner Res,2014,29(10):2238-2249.
[17] SHI H,CHEN M.The brain-bone axis:unraveling the complexinterplay between the central nervous system and skeletal metabolism[J].Eur J Med Res,2024,29(1):317.
[18] YADAV V K,OURY F,SUDA N,et al.A serotonin-dependent mechanism explains the leptin regulation of bone mass,appetite,and energy expenditure[J].Cell,2009,138(5):976-989.
[19] YADAV V K,RYU J H,SUDA N,et al.Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum[J].Cell,2008,135(5):825-837.
[20] WANG C X,GE X Y,WANG M Y,et al.Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells[J].Stem Cell Res Ther,2020,11(1):12.
[21] WANG L,HAN L,XUE P,et al.Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway[J].Cell Signal,2021,78:109847.
[22] OURY F,KHRIMIAN L,DENNY C A,et al.Maternal and offspring pools of osteocalcin influence brain development and functions[J].Cell,2013,155(1):228-241.
[23] NAKAMURA M,IMAOKA M,TAKEDA M.Interaction of bone and brain:osteocalcin and cognition[J].Int J Neurosci,2021,131(11):1115-1123.
[24] 李婷婷,陈凤,刘然.阿尔茨海默病患者血清FGF23和ZAG水平表达与认知功能的相关性分析[J].现代检验医学杂志,2023,38(6):166-169.
[25] 王依宁,廖子蔚,杜娟,等.脑小血管病患者血清3-NT、Hcy、PLR和FGF23水平与认知功能障碍的关系[J].分子诊断与治疗杂志,2023,15(4):665-668.
[26] 马晓伟,田伟,冯文霞,等.外周血Lp-PLA2和FGF23水平变化与脑梗死后认知功能障碍的相关性[J].中国实用神经疾病杂志,2024,27(4):463-467.
[27] DIVOLIS G,STAVROPOULOS A,MANIOUDAKI M,et al.Activation of both transforming growth factor-β and bone morphogenetic protein signalling pathways upon traumatic brain injury restrains pro-inflammatory and boosts tissue reparatory responses of reactive astrocytes and microglia[J].Brain Commun,2019,1(1):fcz028.
[28] 何辉,李雯,刘娟,等.骨形态发生蛋白/维甲酸诱导的神经特异性蛋白3在丙戊酸钠诱导神经干细胞向神经元分化过程中的作用[J].解剖学报,2020,51(6):832-838.
[29] 李红云,裴海涛,汝丽娟.骨形态发生蛋白-7对大鼠脑缺血再灌注后Caspase-3表达的影响[J].解剖学报,2012,43(3):335-339.
[30] UYGUR B,DUBERMAN J,FERGUSON S M.A guide to time lag and time lag shortening strategies in oncology-based drug development[J].J Commer Biotechnol,2017,23:75-81.
[31] ZHU S,PANG Y,XU J,et al.Endocrine regulation on bone by thyroid[J].Front Endocrinol(Lausanne),2022,13:873820.
[32] SUAREZ-BREGUA P,GUERREIRO P M,ROTLLANT J.Stress,glucocorticoids and bone:a review from mammals and fish[J].Front Endocrinol(Lausanne),2018,9:526.
[33] ZHANG L,LIU N,SHAO J,et al.Bidirectional control of parathyroid hormone and bone mass by subfornical organ[J].Neuron,2023,111(12):1914-1932.
[34] WANG T,HE C.TNF-α and IL-6:the link between immune and bone system[J].Curr Drug Targets,2020,21(3):213-227.
[35] MOGHADDASI M,NABOVVATI M,KOUSHKI A,et al.Randomized control trial of evaluation of Clemastine effects on visual evoked potential,nerve fiber layer and ganglion cell layer complex in patients with optic neuritis[J].Clin Neurol Neurosurg,2020,193:105741.
[36] SAILIKE B,ONZHANOVA Z,AKBAY B,et al.Vitamin D in central nervous system:implications for neurological disorders[J].Int J Mol Sci,2024,25(14):7809.
[37] KIM J M,PARK K Y,KIM H R,et al.Association of bone mineral density to cerebral small vessel disease burden[J].Neurology,2021,96(9):e1290-e1300.
[38] YAJUN W,JIN C,ZHENGRONG G,et al.Betaine attenuates osteoarthritis by inhibiting osteoclastogenesis and angiogenesis in subchondral bone[J].Front Pharmacol,2021,12:723988.
[39] REHMAN R,ALAM F,BAIG M,et al.Editorial:vitamin D deficiency and sufficiency in reproduction and bone metabolism[J].Front Endocrinol(Lausanne),2021,12:740021.
[40] SINISCALCHI A,MURPHY S,CIONE E,et al.Antiepileptic drugs and bone health:current concepts[J].Psychopharmacol Bull,2020,50(2):36-44.
[41] AGIRMAN G,YU K B,HSIAO E Y.Signaling inflammation across the gut-brain axis[J].Science,2021,374(6571):1087-1092.
[42] HEATH V.Pharmacotherapy:novel antibody therapy demonstrates potential for building bone in osteoporosis[J].Nat Rev Endocrinol,2014,10(3):125.
[43] 李希宁,董颖,赵宇,等.雷帕霉素通过抑制mTOR通路激活自噬缓解氟骨症大鼠早期的骨质疏松[J].中华劳动卫生职业病杂志,2021,39(5):321-327.

备注/Memo

备注/Memo:
基金项目:江苏省中医药领军人才培养项目(SLJ0310)
江苏省重点学科和医学重点实验室建设项目(苏卫科教〔2022〕17号)
苏州市中医骨科重点实验室建设项目(苏财教〔2022〕141号)
通信作者 E-mail:okdoctor@163.com
更新日期/Last Update: 2025-06-15