[1]欧阳海洋,冯映栋,郑筠炽,等.富血小板血浆联合关节镜下微骨折术治疗距骨软骨损伤的疗效[J].中国中医骨伤科杂志,2025,33(06):34-38.[doi:10.20085/j.cnki.issn1005-0205.250606]
　OUYANG Haiyang,FENG Yingdong,ZHENG Junchi,et al.The Efficacy of Platelet Rich Plasma Combined with Arthroscopic Microfracture Surgery on Osteochondral Lesions of the Talus[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(06):34-38.[doi:10.20085/j.cnki.issn1005-0205.250606]
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富血小板血浆联合关节镜下微骨折术治疗距骨软骨损伤的疗效()

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年06期
页码:
34-38
栏目:
临床研究
出版日期:
2025-06-15

文章信息/Info

Title:
The Efficacy of Platelet Rich Plasma Combined with Arthroscopic Microfracture Surgery on Osteochondral Lesions of the Talus
文章编号:
1005-0205(2025)06-0034-05
作者:
欧阳海洋1; 冯映栋1; 郑筠炽1; 赵家安1△
1中山火炬开发区人民医院(广东 中山,528400)
Author(s):
OUYANG Haiyang1; FENG Yingdong1; ZHENG Junchi1; ZHAO Jiaan1△
1Zhongshan Torch Development Zone People's Hospital,Zhongshan 528400,Guangdong China.
关键词:
富血小板血浆;  关节镜下微骨折术;  距骨软骨损伤
Keywords:
platelet rich plasma;  arthroscopic microfracture surgery;  osteochondral lesions of the talus
分类号:
R681.8
DOI:
10.20085/j.cnki.issn1005-0205.250606
文献标志码:
A
摘要:
目的:探究富血小板血浆(PRP)联合关节镜下微骨折术在距骨软骨损伤(OLT)患者治疗中的临床疗效。方法:选取2021年8月至2023年12月接受治疗的84例距骨软骨损伤患者作为研究对象,分为对照组和联合组(各42例),对照组患者接受关节镜下微骨折术治疗,联合组患者在对照组治疗的基础上注射富血小板血浆进行联合治疗。对患者的疗效、踝关节液中间质细胞衍生因子-1(SDF-1)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平及安全性进行分析。结果:治疗后,联合组患者的临床有效率明显优于对照组,差异有统计学意义(P<0.05); 联合组患者的视觉模拟量表(VAS)评分、IL-1β、SDF-1与TNF-α水平低于对照组,差异有统计学意义(P<0.05),美国足踝外科协会(AOFAS)评分、踝关节背伸活动度和跖屈活动度则明显高于对照组(P<0.05)。在治疗过程中,两组患者出现不良反应的发生率差异无统计学意义(P>0.05)。结论:富血小板血浆联合关节镜下微骨折术应用于距骨软骨损伤的治疗,具有较好的疗效,可以显著降低患者的IL-1β和SDF-1水平,改善患者的踝关节功能,安全可靠。
Abstract:
Objective:To investigate the clinical efficacy of platelet rich plasma(PRP)combined with arthroscopic microfracture surgery on osteochondral lesions of the talus(OLT)patients.Methods:A total of 84 OLT patients were selected as research subjects and followed up,who received treatment from August 2021 to December 2023.They were grouped into control group(42 cases)and combined group(42 cases).The control group received arthroscopic microfracture treatment,while the combined group received PRP injection for combination treatment on the basis of the control group.The efficacy,ankle joint fluid stromal cell-derived factor-1(SDF-1),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)levels,and safety were analyzed.Results:After treatment,the clinical effective rate of the combined group was greatly better than that of the control group(P<0.05).The visual analogue scale(VAS)score,IL-1β,SDF-1,and TNF-α levels in the combined group were lower than those in the control group(P<0.05),while the American orthopaedic foot and ankle society(AOFAS)score,ankle dorsiflexion range of motion,and plantarflexion range of motion were greatly higher than those in the control group(P<0.05).During the treatment process,there was no significant difference in the frequency of adverse reactions between the two groups(P>0.05).Conclusion:The application of PRP combined with arthroscopic microfracture surgery has good efficacy in treating OLT.It can greatly reduce the levels of IL-1β and SDF-1 in patients,improve ankle joint function,and demonstrate safety and reliability.

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备注/Memo

备注/Memo:
基金项目:中山市社会公益与基础研究项目(2023B1116)
△通信作者 E-mail:y53e4q@163.com
更新日期/Last Update: 2025-06-15