[1]周海东,卢姚宏,胡文涛,等.舒筋消痛胶囊治疗湿瘀痹阻型膝骨关节炎的临床观察[J].中国中医骨伤科杂志,2025,33(05):17-21.[doi:10.20085/j.cnki.issn1005-0205.250504]
　ZHOU Haidong,LU Yaohong,HU Wentao,et al.Clinical Observation of Shujin Xiaotong Capsule in the Treatment of Knee Osteoarthritis with Dampness-Stasis Obstruction[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(05):17-21.[doi:10.20085/j.cnki.issn1005-0205.250504]
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舒筋消痛胶囊治疗湿瘀痹阻型膝骨关节炎的临床观察()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年05期
页码:
17-21
栏目:
临床研究
出版日期:
2025-05-05

文章信息/Info

Title:
Clinical Observation of Shujin Xiaotong Capsule in the Treatment of Knee Osteoarthritis with Dampness-Stasis Obstruction
文章编号:
1005-0205(2025)05-0017-05
作者:
周海东1; 2; 卢姚宏1; 胡文涛1; 林茂华1; 谢杰飞1; 胡梁深2; 龚礼2; 徐睿琛2; 单记春2; 范少勇2; 陈虞文3△
1江西中医药大学(南昌,330004); 2江西中医药大学附属洪都中医院; 3江西中医药大学附属医院
Author(s):
ZHOU Haidong1; 2; LU Yaohong1; HU Wentao1; LIN Maohua1; XIE Jiefei1; HU Liangshen2; GONG Li2; XU Ruichen2; SHAN Jichun2; FAN Shaoyong2; CHEN Yuwen3△
1Jiangxi University of Chinese Medicine,Nanchang 330004,China; 2Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Chinese Medicine,Nanchang 330038,China; 3Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China.
关键词:
舒筋消痛胶囊;  湿瘀痹阻型;  膝骨关节炎;  中药治疗;  临床疗效
Keywords:
Shujin Xiaotong capsule;  wet stasis arthralgia type;  knee osteoarthritis;  Chinese medicine treatment;  clinical effect
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.250504
文献标志码:
A
摘要:
目的:观察舒筋消痛胶囊治疗湿瘀痹阻型膝骨关节炎(KOA)的临床疗效。方法:选取符合湿瘀痹阻型膝骨关节炎诊断标准的受试者112例,随机分为观察组和对照组,每组各56例。观察组服用舒筋消痛胶囊(3次/d,3粒/次),对照组服用塞来昔布胶囊(2次/d,1粒/次),疗程均为4周,观察两组受试者的WOMAC评分、Lysholm评分、VAS评分变化及血清IL-6、TNF-α水平,并监测治疗期间的不良反应,在治疗结束后6个月进行随访,记录其复发率。结果:治疗结束后,观察组VAS评分、WOMAC评分和IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05); 观察组Lysholm评分高于对照组,差异有统计学意义(P<0.05); 观察组的总有效率(92.86%)高于对照组(80.36%); 观察组的复发率为11.54%,低于对照组的28.89%,差异有统计学意义(P<0.05); 治疗期间观察组未见明显不良反应。结论:舒筋消痛胶囊在改善湿瘀痹阻型膝骨关节炎患者疼痛、关节功能及炎症因子方面疗效显著,且安全性良好,适合临床推广应用。
Abstract:
Objective:To observe the clinical effect of Shujin Xiaotong capsule in treating knee osteoarthritis(KOA).Methods:A total of 112 subjects conforming to the diagnostic criteria of KOA were randomly divided into observation group and control group,with 56 cases in each group.The observation group took Shujin Xiaotong capsule(3 capsules/times,3 times a day),and the control group took celeoxib capsule(1 capsule/times,twice a day)for 4 weeks.The changes of WOMAC,Lysholm,VAS scores and serum levels of IL-6 and TNF-α of subjects in both groups were observed,and the adverse reactions during treatment were monitored.The recurrence rate was recorded at 6 months after the end of treatment.Results:After treatment,VAS,WOMAC scores,IL-6,TNF-α levels in observation group were lower than those in control group(P<0.05),Lysholm scores in observation group were higher than those in control group(P<0.05).The total effective rate of the observation group(92.86%)was better than that of the control group(80.36%),the recurrence rate of the observation group was 11.54%,lower than 28.89% of the control group,and no obvious adverse reactions were observed in the observation group during the treatment.Conclusion:Shujin Xiaotong capsule has significant efficacy in improving pain,joint function and inflammatory factors in patients with damp stasis obstruction type KOA,and has good safety,which is suitable for clinical application.

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备注/Memo

备注/Memo:
基金项目:江西省重点研发计划项目(20202BBG73028)
2024年江西省校级大学生创新创业训练计划项目(202410412281)
2024年江西省研究生创新专项资金项目(YC2024-B239)
江西省教育厅科学技术研究项目(GJJ2200986)
△通信作者 E-mail:594049402@qq.com
更新日期/Last Update: 2025-05-15