[1]张兵兵,孔海英,崔龙慷,等.紫黄膏穴位贴敷联合富血小板血浆治疗膝骨关节炎的临床研究[J].中国中医骨伤科杂志,2025,33(05):13-16+21.[doi:10.20085/j.cnki.issn1005-0205.250503]
　ZHANG Bingbing,KONG Haiying,CUI Longkang,et al.Clinical Study of Zihuang Plaster Combined with Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(05):13-16+21.[doi:10.20085/j.cnki.issn1005-0205.250503]
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紫黄膏穴位贴敷联合富血小板血浆治疗膝骨关节炎的临床研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年05期
页码:
13-16+21
栏目:
临床研究
出版日期:
2025-05-05

文章信息/Info

Title:
Clinical Study of Zihuang Plaster Combined with Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis
文章编号:
1005-0205(2025)05-0013-04
作者:
张兵兵1; 孔海英2; 崔龙慷1; 沈高波1; 朱宇尘1; 吴连国1△
1浙江中医药大学附属第二医院(杭州,310005); 2浙江省医疗健康集团杭州医院
Author(s):
ZHANG Bingbing1; KONG Haiying2; CUI Longkang1; SHEN Gaobo1; ZHU Yuchen1; WU Lianguo1△
1The Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,China. 2Zhejiang Medical and Health Group Hangzhou Hospital,Hangzhou 310022,China.
关键词:
膝骨关节炎;  紫黄膏;  穴位贴敷;  富血小板血浆;  气滞血瘀证
Keywords:
knee osteoarthritis;  Zihuang plaster;  acupoint application;  platelet-rich plasma;  Qi stagnation and blood stasis
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.250503
文献标志码:
A
摘要:
目的:观察紫黄膏穴位贴敷联合富血小板血浆治疗膝骨关节炎(气滞血瘀证)的临床疗效。方法:将2023年1月至2024年1月收集的膝骨关节炎(气滞血瘀证)患者60例,随机分为对照组和观察组各30例。对照组患者采用富血小板血浆关节腔注射治疗,观察组患者采用紫黄膏贴敷联合富血小板血浆关节腔注射治疗。治疗3周后,评价两组患者临床疗效及安全性,并比较两组治疗前后视觉模拟量表(VAS)评分、中医证候评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分及血清炎症因子水平(血清IL-1β和TNF-α)。结果:观察组患者总有效率(96.67%)高于对照组(80.00%),差异有统计学意义(P<0.05)。治疗前,两组患者中医证候评分、VAS评分、WOMAC评分及血清炎症因子水平比较,差异无统计学意义(P>0.05); 治疗后,两组患者上述指标均较治疗前降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应比较,差异无统计学意(P>0.05)。结论:紫黄膏穴位贴敷联合富血小板血浆治疗膝骨关节炎(气滞血瘀证)疗效显著,在改善中医证候评分、VAS评分、WOMAC评分及炎症因子水平方面优于单纯富血小板血浆关节腔注射治疗。
Abstract:
Objective:To observe the clinical efficacy of Zihuang plaster acupoint application combined with platelet-rich plasma in the treatment of knee osteoarthritis with Qi stagnation and blood stasis.Methods:A total of 60 knee osteoarthritis patients with Qi stagnation and blood stasis collected from January 2023 to January 2024 were selected and divided into control group and observation group,with 30 cases in each group.The control group was treated with platelet-rich plasma,and the observation group was treated with Zihuang plaster acupoint application combined with platelet-rich plasma.After 3 weeks of treatment,the clinical efficacy and safety of the two groups were evaluated,and the visual analogue scale(VAS)score,traditional Chinese medicine(TCM)syndrome score,Western Ontario and McMaster University osteoarthritis index(WOMAC)score,and serum inflammatory factor levels(serum IL-1β and TNF-α)were compared between the two groups before and after treatment.Results:The total effective rate of the observation group was 96.67%,significantly higher than 80.00% of the control group(P<0.05).Before treatment,there was no significant difference in TCM syndrome score,VAS score,WOMAC score,and serum inflammatory factor level between the two groups(P>0.05).After treatment,the above indexes in the two groups were lower than those before treatment,and the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Zihuang plaster acupoint application combined with platelet-rich plasma in the treatment of knee osteoarthritis with Qi stagnation and blood stasis is more effective than that of platelet-rich plasma in improving TCM syndrome score,VAS score,WOMAC score and inflammatory factor levels.

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备注/Memo

备注/Memo:
基金项目:浙江省“领雁”研发攻关计划项目(2024C03213)
浙江省中医药科技计划项目(2024ZL514)
△通信作者 E-mail:mdwu8535@126.com
更新日期/Last Update: 2025-05-15