[1]方诗元,覃健,张利勇,等.盘龙七片治疗骨折早期的真实世界研究[J].中国中医骨伤科杂志,2025,33(03):48-55+63.[doi:1005-0205(2025)03-0048-08]
　FANG Shiyuan,QIN Jian,ZHANG Liyong,et al.Real-World Study on the Treatment of Early Fractures with Panlongqi Tablets[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(03):48-55+63.[doi:1005-0205(2025)03-0048-08]
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盘龙七片治疗骨折早期的真实世界研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年03期
页码:
48-55+63
栏目:
临床研究
出版日期:
2025-03-15

文章信息/Info

Title:
Real-World Study on the Treatment of Early Fractures with Panlongqi Tablets
文章编号:
10.20085/j.cnki.issn1005-0205.250309
作者:
方诗元1;  覃健2;  张利勇3;  吴泽荣4;  郭团茂5;  董婷6;  徐玮1;  杨家赵1;  张春闩7;  王伟伟8;  何斌9;  冯琴琴10;  李程11;  夏泉12;  方先骏12;  蔡和平13;  贾长军14;  徐喜卿15;  于明伟16;  黄承夸17;  孙超18;  张红19;  张艳丽20;  陈磊21;  刘斌1△
1中国科学技术大学附属第一医院(合肥,230001);2南京医科大学附属逸夫医院;3扬州市中医院;4深圳宝安中医院;5咸阳中心医院;6杭州市富阳中医骨伤医院;7庐江县中医院;8南京市中医院;9南京医科大学第二附属医院;10兵器工业五二一医院;11西北大学附属医院(西安市第三医院);12安徽医科大学第一附属医院;13安徽省儿童医院;14葫芦岛市第二人民医院;15淄博中心医院;16烟台毓璜顶医院;17右江民族医学院附属西南医院暨百色市人民医院;18山东大学第二医院;19南京市高淳人民医院;20上海市松江中心医院;21中国药科大学
Author(s):
FANG Shiyuan1;  QIN Jian2;  ZHANG Liyong3;  WU Zerong4;  GUO Tuanmao5;  DONG Ting6;  XU Wei1;  YANG Jiazhao1;  ZHANG Chunshuan7;  WANG Weiwei8;  HE Bin9;  FENG Qinqin10;  LI Cheng11;  XIA Quan12;  FANG Xianjun12;  CAI Heping13;  JIA Changjun14;  XU Xiqing15;  YU Mingwei16;  HUANG Chengkua17;  SUN Chao18;  ZHANG Hong19;  ZHANG Yanli20;  CHEN Lei21;  LIU Bin1△
1First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,China; 2Sir Run Run Hospital Affiliated to Nanjing Medical University,Nanjing 211198,China; 3Yangzhou Traditional Chinese Medicine Hospital,Yangzhou 225100,Jiangsu China; 4 Shenzhen Baoan Traditional Chinese Medicine Hospital, Shenzhen 518100,Guangdong China; 5Xianyang Central Hospital,Xianyang 712000,Shaanxi China; …
关键词:
真实世界研究;  早期骨折;  倾向匹配得分法;  患者报告结局;  健康相关生命质量
Keywords:
real-world research;  fracture;  propensity matching score method;  patient reported outcome;  health-related quality of life
分类号:
R683
DOI:
1005-0205(2025)03-0048-08
文献标志码:
A
摘要:
目的:基于真实世界研究评价盘龙七片对比接骨七厘片治疗骨折的有效性和安全性。方法:研究纳入20余家入组医院2021年9月至2023年9月期间6 654例骨折早期患者,依据中西医骨折诊断标准分为观察组患者3 706例,对照组患者2 948例。观察组在常规治疗础上联用盘龙七片,对照组在常规治疗基础上联用接骨七厘片。通过电话回访收集骨折后第1,4,7,14天的患者自报告指标,将疼痛评分改善值、肿胀评分改善值、EQ-5D评分改善值作为疗效指标,将药物不良反应作为安全性指标。采用倾向匹配得分法(PSM)对患者年龄、性别、骨折部位、骨折严重程度、手术类型、联合用药等指标进行基线匹配,最后对各疗效指标进行统计分析。结果:观察组(A组)患者的疼痛评分差异有统计学意义(PSM后4.761比4.617,P<0.01),降低效果显著; 肿胀分级评分差异有统计学意义(PSM后2.984比2.697,P<0.01),降低效果显著; 效用值改善效果显著,差异有统计学意义(PSM后0.430比0.406,P<0.01); 有效率改善效果显著,差异有统计学意义(PSM后87.20%比80.57%,P<0.01)。安全性方面,两组均无严重不良反应,不良反应率都低于1%,差异无统计学意义(P>0.01)。结论:盘龙七片在改善骨折患者疼痛、肿胀、效用值和有效率方面均显著优于接骨七厘片,安全性较好。
Abstract:
Objective:To evaluate the effectiveness and safety of Panlongqi tablets and Jiegu Qili tablets in the treatment of fractures based on real-world research.Methods:The study enrolled 6 654 early-stage fracture patients across more than 20 participating hospitals from September 2021 to September 2023.According to the diagnostic criteria for fractures in both traditional Chinese and Western medicine,3 706 patients were assigned to the observation group,while 2 948 patients were assigned to the control group.The control group received routine care combined with Jiegu Qili tablets,whereas the observation group received routine care combined with Panlongqi tablets.Patient-reported outcomes were collected via telephone follow-up at 1,4,7,and 14 d post-fracture.Improvement in pain scores,swelling scores,and EQ-5D scores served as efficacy indicators,while adverse drug reactions were monitored as safety indicators.The propensity score matching(PSM)method was utilized to ensure baseline comparability among patients based on age,gender,fracture location,fracture severity,surgical type,and concomitant therapies.Subsequently,statistical analyses were conducted on each efficacy indicator.Results:The observation group showed a significant decrease in pain score(4.761 vs 4.617 after PSM,P<0.01),swelling grading score(2.984 vs 2.697 after PSM,P<0.01),improvement in utility value(0.430 vs 0.406 after PSM,P<0.01),and effective improvement of the effect(87.20% vs 80.57% after PSM,P<0.01)compared to the control group.In terms of safety,there were no serious adverse reactions in the two groups,and the adverse reaction rate was less than 1%,and the difference was not statistically significant.Conclusion:Panlongqi tablets is significantly better than Jiegu Qili tablets in improving pain,swelling,utility value,and effective rate in patients with fractures,and has good safety.

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更新日期/Last Update: 2025-03-10