[1]姜昊南,吕浩,曲宇豪,等.桃红四物汤加味对血瘀型腰椎间盘突出症髓核形态改变的影响[J].中国中医骨伤科杂志,2025,33(03):43-47.[doi:1005-0205(2025)03-0043-05]
 JIANG Haonan,L Hao,QU Yuhao,et al.Effect of Modified Taohong Siwu Decoction of Nucleus Pulposus in Blood Stasis Lumbar Disc Herniation[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(03):43-47.[doi:1005-0205(2025)03-0043-05]
点击复制

桃红四物汤加味对血瘀型腰椎间盘突出症髓核形态改变的影响()
分享到:

《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年03期
页码:
43-47
栏目:
临床研究
出版日期:
2025-03-15

文章信息/Info

Title:
Effect of Modified Taohong Siwu Decoction of Nucleus Pulposus in Blood Stasis Lumbar Disc Herniation
文章编号:
10.20085/j.cnki.issn1005-0205.250308
作者:
姜昊南1 吕浩1 曲宇豪1 王岩1 江渟2△ 张建华2
1安徽中医药大学第一临床医学院(合肥,230012)
2安徽中医药大学第一附属医院
Author(s):
JIANG Haonan1 LÜ Hao1 QU Yuhao1 WANG Yan1 JIANG Ting2△ ZHANG Jianhua2
1The First Clinical Medical School of Anhui University of Chinese Medicine,Hefei 230012,China; 2The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China.
关键词:
腰椎间盘突出症 桃红四物汤 血瘀型 髓核形态 重吸收
Keywords:
lumbar disc herniation Taohong Siwu decoction blood stasis nucleus pulposus morphology reabsorption
分类号:
R681.5
DOI:
1005-0205(2025)03-0043-05
文献标志码:
A
摘要:
目的:探讨桃红四物汤加味对血瘀型腰椎间盘突出髓核形态的影响。方法:对2022年9月至2023年12月期间收治的30例接受保守治疗的腰椎间盘突出症患者的临床资料进行回顾性分析,保守治疗接受中药桃红四物汤加减口服,比较治疗前及6个月后随访的突出髓核体积大小、疼痛视觉模拟量表(VAS)评分、Oswestry功能障碍指数(ODI)评分、髓核突出率、髓核突出物体积、重吸收率,评估临床疗效及转归预后。结果:30例患者中重吸收发生率为53.33%(16/30),初诊与末次随访VAS评分、腰椎ODI评分、髓核突出率、髓核突出物体积各项指标比较,差异均有统计学意义(P<0.05)。结论:桃红四物汤加味可以改善血瘀型腰椎间盘突出症患者的疼痛症状,促使突出的髓核体积减小,诱导突出的椎间盘重吸收。
Abstract:
Objective:4To investigate the effect of modified Taohong Siwu decoction on the morphology of nucleus pulposus herniated in the lumbar intervertebral disc with blood stasis.Methods:The clinical data of 30 patients with lumbar intervertebral disc herniation who were admitted to the hospital from September 2022 to December 2023 were retrospective analyzed,and the volume of the herniated nucleus pulposus,the pain visual analogue scale(VAS)score,and the Oswestry disability index(ODI)score were compared before treatment and 6 months after the follow-up.The nucleus pulposus herniation rate,nucleus pulposus protrusion volume,and reabsorption rate were evaluated for clinical efficacy and prognosis.Results:The incidence of reabsorption was 53.33%(16/30)in 30 patients,and there were statistically significant differences in VAS score,lumbar ODI score,nucleus pulposus herniation rate,and nucleus pulposus protrusion volume between the first diagnosis and the last follow-up(P<0.05).Conclusion:Taohong Siwu decoction can improve the pain symptoms of patients with blood stasis lumbar disc herniation,promote the reduction of the volume of herniated nucleus pulposus,and induce the reabsorption of herniated intervertebral discs.

参考文献/References:

[1] 中华医学会骨科学分会脊柱外科学组,中华医学会骨科学分会骨科康复学组.腰椎间盘突出症诊疗指南[J].中华骨科杂志,2020,40(8):477-487.
[2] DEYO R A,MIRZA S K.CLINICAL PRACTICE.Herniated lumbar intervertebral disk[J].N Engl J Med,2016,374(18):1763-1772
[3] CHIU C C,CHUANG T Y,CHANG K H,et al.The probability of spontaneous regression of lumbar herniated disc:a systematic review[J].Clinical Rehabilitation,2015,29(2):184.
[4] 张晶博,王想福,孙凤岐,等.中医药促进腰椎间盘突出后重吸收作用的研究进展[J].中国民族民间医药,2024,33(6):57-62.
[5] 王星宇,江渟.桃红四物汤加味用于腰椎间盘突出症UBE术后的临床疗效观察[J].中医药临床杂志,2024,36(3):560-564.
[6] 中华医学会疼痛学分会脊柱源性疼痛学组.腰椎间盘突出症诊疗中国疼痛专家共识[J].中国疼痛医学杂志,2020,26(1):2-6.
[7] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:201-202.
[8] YU P F,JIANG F D,LIU J T,et al.Outcomes of conservative treatment for ruptured lumbar disc herniation[J].Acta Orthop Belg,2013,79(6):726-730.
[9] HUSKISSON E C.Measurement of pain[J].Lancet,1974,2(7889):1127-1131.
[10] FAIRBANK J C T,PYNSENT P B.The Oswestry disability index[J].Spine,2000,25(22):2940-2953.
[11] 葛龙,李镜,尚文茹,等.非手术疗法治疗腰椎间盘突出症的循证实践指南[J].中国循证医学杂志,2024,24(2):125-148.
[12] 林顺,孙一夫,俞鹏飞,等.腰椎间盘突出后重吸收研究进展[J].中国中医骨伤科杂志,2022,30(4):85-88.
[13] 孙一夫,姜宏,俞鹏飞,等.腰椎间盘髓核脱出重吸收的研究进展[J].中国矫形外科杂志,2022,30(15):1381-1385.
[14] 张晗祥,何斌,吴永铁,等.Sdf1/Cxcr4轴通过Pi3k/Akt通路对退变椎间盘血管长入发挥作用[J].中国矫形外科杂志,2019,27(7):633-640.
[15] DJURIC N,YANG X,EL BARZOUHI A,et al.Lumbar disc extrusions reduce faster than bulging discs due to an active role of macrophages in sciatica[J].Acta Neurochir(Wien),2020,162(1):79-85.
[16] OHBA T,HARO H.TWEAK and TSLP in disc degeneration and spontaneous hernia resorption[J].JOR Spine,2020,3(1):e1068.
[17] 李晓春,姜宏,刘锦涛,等.益气化瘀方促进破裂型腰椎间盘突出重吸收机制的探讨[J].中国中医骨伤科杂志,2011,19(5):7-9.
[18] 刁志君,姜宏,刘锦涛,等.益气活血方介导促炎因子促进破裂型腰椎间盘突出后重吸收的机制研究[J].中国中医骨伤科杂志,2019,27(5):1-6.
[19] 乔明珠,吕浩,江渟.基于网络药理学研究桃红四物汤干预腰椎间盘突出症的机制[J].安徽中医药大学学报,2022,41(2):60-67.
[20] 陈恋戈,李孔正,朱炯端.桃红四物汤辨证加减配合中医骨伤手法治疗腰椎间盘突出症(气滞血瘀证)的疗效分析[J].中医临床研究,2019,11(4):53-56.
[21] 聂欣,成颜芬,王琳,等.桃红四物汤化学成分、药理作用、临床应用的研究进展及质量标志物的预测分析[J].中国实验方剂学杂志,2020,26(4):226-234.

备注/Memo

备注/Memo:
基金项目:新安医学教育部重点实验室开放基金项目(2022XAYX12)
通信作者 E-mail:jiangting70@163.com
更新日期/Last Update: 2025-03-10