[1]夏雪,沈霖△,帅波△,等.加味青娥丸治疗肾虚血瘀型膝骨关节炎合并骨质疏松症的疗效观察[J].中国中医骨伤科杂志,2025,33(01):52-55.[doi:10.20085/j.cnki.issn1005-0205.250111]
　XIA Xue,SHEN Lin,SHUAI Bo,et al.Clinical Efficacy of Jiawei Qing'e Pill on the Treatment of Knee Osteoarthritis of Kidney Deficiency and Blood Stasis Type Combined Osteoporosis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(01):52-55.[doi:10.20085/j.cnki.issn1005-0205.250111]
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加味青娥丸治疗肾虚血瘀型膝骨关节炎合并骨质疏松症的疗效观察()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年01期
页码:
52-55
栏目:
临床研究
出版日期:
2025-01-15

文章信息/Info

Title:
Clinical Efficacy of Jiawei Qing'e Pill on the Treatment of Knee Osteoarthritis of Kidney Deficiency and Blood Stasis Type Combined Osteoporosis
文章编号:
1005-0205(2025)01-0052-04
作者:
夏雪1; 沈霖2△; 帅波2△; 凌家艳1
1武汉市中西医结合医院(武汉,430022)
2华中科技大学同济医学院附属协和医院
Author(s):
XIA Xue1; SHEN Lin2△; SHUAI Bo2△; LING Jiayan1
1Wuhan Hospital of Traditional Chinese and Western Medicine,Wuhan 430022,China; 2Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China.
关键词:
加味青娥丸;  膝关节;  骨质疏松症;  骨代谢指标;  炎症因子
Keywords:
Jiawei Qing'e pill;  knee joint;  osteoporosis;  bone metabolism index;  inflammatory factors
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.250111
文献标志码:
A
摘要:
目的:探讨加味青娥丸治疗肾虚血瘀型膝骨关节炎合并骨质疏松症的临床疗效及对骨代谢水平和炎症因子的影响。方法:选择80名膝骨关节炎并伴有骨质疏松症的患者作为研究对象,随机分为观察组和对照组,各40例。观察组患者服用加味青娥丸12周,对照组患者口服塞来昔布2周及阿仑膦酸钠12周。观察治疗前后两组患者视觉模拟量表(VAS)评分、西安大略和麦克斯特大学(WOMAC)骨关节炎指数评分、骨代谢指标及炎症因子水平。结果:治疗后患者VAS评分和WOMAC评分较治疗前差异有统计学意义(P<0.05),且治疗后观察组评分明显低于对照组,差异有统计学意义(P<0.05); 治疗后患者β-CTX及PINP水平较治疗前差异有统计学意义(P<0.05),治疗后观察组水平明显低于对照组,差异有统计学意义(P<0.05); 治疗后患者IL-6、TNF-α、IL-10水平较治疗前差异有统计学意义(P<0.05),观察组水平明显低于对照组,差异有统计学意义(P<0.05)。结论:加味青娥丸能明显缓解膝骨关节炎合并骨质疏松症患者临床症状,同时调节骨代谢标志物,改善炎症水平。
Abstract:
Objective:To investigate the clinical efficacy of Jiawei Qing'e pill on the treatment of knee osteoarthritis(KOA)with kidney deficiency and blood stasis type combined with osteoporosis(OP),and its efficacy on bone metabolism and inflammatory factors.Methods:A total of 80 patients with KOA complicated with OP were selected as the research objects,and were randomly divided into observation group(40 cases)and control group(40 cases).The observation group was treated with Jiawei Qing'e pill for 12 weeks,and the control group was treated with oral celecoxib for 2 weeks and alendronate for 12 weeks.The visual analogue scale(VAS)scores,Western Ontario and McMaster Universities(WOMAC)osteoarthritis index scores,bone metabolism indexes and inflammatory factors of the two groups were observed before and after treatment.Results:After treatment,the levels of VAS scores and WOMAC scoresin the observation group were significantly lower than those in the control group(P<0.05),and the levels of β-CTX and PINP in the observation group were significantly lower than those in the control group(P<0.05).The levels of VAS scores and WOMAC scores in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of IL-6,TNF-α and IL-10 were statistically different from those before treatment(P<0.05),and the levels in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Jiawei Qing'e pills can effectively relieve the clinical symptoms of KOA patients with OP,regulate bone metabolism markers,and improve the level of inflammation.

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备注/Memo

备注/Memo:
基金项目:中央高校基本科研业务费专项基金项目(2019kfyRCPY093)
△通信作者 E-mail:shenlinhb@sina.cn(沈霖)
bobo3137@126.com(帅波)
更新日期/Last Update: 2025-01-15