[1]沈高波,崔龙慷△,张兵兵,等.骨痹饮治疗膝骨关节炎的临床疗效及对骨髓病变的影响[J].中国中医骨伤科杂志,2025,33(01):42-47.[doi:10.20085/j.cnki.issn1005-0205.250109]
　SHEN Gaobo,CUI Longkang,ZHANG Bingbing,et al.Effect of Gubi Yin on Clinical Efficacy and Bone Marrow Lesions of Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(01):42-47.[doi:10.20085/j.cnki.issn1005-0205.250109]
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骨痹饮治疗膝骨关节炎的临床疗效及对骨髓病变的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年01期
页码:
42-47
栏目:
临床研究
出版日期:
2025-01-15

文章信息/Info

Title:
Effect of Gubi Yin on Clinical Efficacy and Bone Marrow Lesions of Knee Osteoarthritis
文章编号:
1005-0205(2025)01-0042-06
作者:
沈高波1; 2; 崔龙慷2△; 张兵兵2; 余阳1; 叶晓昂1; 吴连国2
1浙江中医药大学(杭州,310053)
2浙江中医药大学附属第二医院
Author(s):
SHEN Gaobo1; 2; CUI Longkang2△; ZHANG Bingbing2; YU Yang1; YE Xiaoang1; WU Lianguo2
1Zhejiang Chinese Medical University,Hangzhou 310053,China; 2Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,China.
关键词:
膝骨关节炎;  骨痹饮;  磁共振膝骨关节炎评分;  骨髓病变;  肾虚血瘀
Keywords:
knee osteoarthritis;  Gubi Yin;  MRI osteoarthritis knee score;  bone marrow lesion;  kidney deficiency and blood stasis
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.250109
文献标志码:
A
摘要:
目的:研究骨痹饮治疗肾虚血瘀型膝骨关节炎的临床疗效及对MRI膝骨关节炎评分(MOAKS)的影响。方法:收集2023年1月至2023年12月就诊的符合膝骨关节炎(KOA)诊断标准和纳入标准的患者60例,随机分为骨痹饮组和对照组(各30例)。骨痹饮组患者予以骨痹饮治疗6周,对照组患者予氨基葡萄糖治疗6周,记录两组患者治疗前后WOMAC评分、Lequesne评分、视觉模拟量表(VAS)评分及MOAKS评分,随访至治疗后第12周,评价两组患者的临床疗效。结果:骨痹饮组患者在治疗后及治疗后第12周WOMAC评分、Lequesne评分及VAS评分低于对照组,差异有统计学意义(P<0.05),组内对比较治疗前明显下降; 骨痹饮组MOAKS骨髓病变评分低于对照组,差异有统计学意义(P<0.05),而骨痹饮组MOAKS关节软骨评分与对照组无明显差异(P>0.05); 两组患者出现胃肠道副反应差异无统计学意义(P>0.05)。结论:骨痹饮可以改善膝骨关节炎患者的临床症状,减轻疼痛,抑制膝关节软骨下骨髓病变,短期内具有良好的临床疗效。
Abstract:
Objective:To study the clinical efficacy of Gubi Yin on knee osteoarthritis(KOA)with kidney deficiency and blood stasis and its effect on MRI osteoarthritis knee score(MOAKS)system.Methods:60 patients who met the KOA diagnostic criteria and inclusion criteria were randomly divided into Gubi Yin group and control group from January 2023 to December 2023,with 30 cases in each group.Patients in the Gubi Yin group were treated with Gubi Yin for 6 weeks,and patients in the control group were treated with glucosamine for 6 weeks.The WOMAC score,Lequesne score,visual analogue scale(VAS)score and MOAKS of patients in both groups were recorded before and after treatment,and were followed up until 12 weeks after treatment to evaluate the clinical efficacy of the two groups.Results:The WOMAC score,Lequesne score and VAS score of Gubi Yin group were lower than those of the control group after treatment and 12 weeks after treatment,the differences were statistically significant(P<0.05),and the intra-group comparison showed that those after treatment was significantly lower than before treatment.The MOAKS bone marrow lesion score of the Gubi Yin group was lower than that of the control group,and the difference was statistically significant(P<0.05),while the MOAKS articular cartilage score of the Gubi Yin group was not significantly different from that of the control group(P>0.05).There was no statistical difference in gastrointestinal side effects between the two groups(P>0.05).Conclusion:Gubi Yin can improve the clinical symptoms of KOA patients,relieve pain,inhibit the knee subchondral bone marrow lesions,and has a good short-term clinical efficacy.

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备注/Memo

备注/Memo:
基金项目:浙江中医药大学科研项目(2023JKJNTZ17,2023JKZKTS41)
浙江省中医药科技计划项目(2024ZL514,2025ZR131)
浙江省“领雁”研发攻关计划项目(2024C03213)
△通信作者 E-mail:1047750337@qq.com
更新日期/Last Update: 2025-01-15