[1]康俊峰,揭立士,廖太阳,等.膝痹宁Ⅱ治疗寒湿痹阻型膝骨关节炎的随机对照研究[J].中国中医骨伤科杂志,2025,33(01):27-32.[doi:10.20085/j.cnki.issn1005-0205.250106]
　KANG Junfeng,JIE Lishi,LIAO Taiyang,et al.Randomized Controlled Study on the Treatment of Osteoarthritis with Cold and Dampness Obstruction by XibiningⅡ[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2025,33(01):27-32.[doi:10.20085/j.cnki.issn1005-0205.250106]
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膝痹宁Ⅱ治疗寒湿痹阻型膝骨关节炎的随机对照研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第33卷
期数:
2025年01期
页码:
27-32
栏目:
临床研究
出版日期:
2025-01-15

文章信息/Info

Title:
Randomized Controlled Study on the Treatment of Osteoarthritis with Cold and Dampness Obstruction by XibiningⅡ
文章编号:
1005-0205(2025)01-0027-06
作者:
康俊峰1; 2; 揭立士1; 3; 廖太阳1; 3; 梅伟1; 3; 吴鹏1; 3; 李晓辰1; 3; 张立1; 3; 王培民1; 3; 茆军1; 3△
1南京中医药大学附属医院(南京,210029)
2山西中医药大学附属医院
3南京中医药大学第一临床医学院
Author(s):
KANG Junfeng1; 2; JIE Lishi1; 3; LIAO Taiyang1; 3; MEI Wei1; 3; WU Peng1; 3; LI Xiaochen1; 3; ZHANG Li1; 3; WANG Peimin1; 3; MAO Jun1; 3△
1Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China; 2Affiliated Hospital of Shanxi University of Chinese Medicine,Taiyuan 030024,China; 3First Clinical Medical College of Nanjing University of Chinese Medicine,Nanjing 210023,China.
关键词:
膝骨关节炎;  寒湿痹阻型;  疼痛;  膝痹宁Ⅱ;  随机对照研究
Keywords:
knee osteoarthritis;  cold-dampness impediment type;  pain;  Xibining Ⅱ;  randomized controlled study
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.250106
文献标志码:
A
摘要:
目的:探索膝痹宁Ⅱ在寒湿痹阻型膝骨关节炎治疗中的有效性和安全性。方法:采用随机对照单盲方法,将80例膝骨关节炎患者分为两组,对照组单纯予塞来昔布胶囊口服,观察组单纯予膝痹宁Ⅱ口服,对照组服药2周,观察组服药4周。观察两组患者治疗前后疼痛视觉模拟量表(VAS)评分、骨关节炎指数(WOMAC)评分、中医证候评分及疗效评估结果。结果:经治疗后,观察组的VAS评分、WOMAC总分、疼痛、关节功能评分、中医证候评分以及疗效评价评估得分均明显低于对照组,差异有统计学意义(P<0.05)。然而,在 WOMAC 僵硬评分方面,观察组与治疗前相比没有显著变化,差异无统计学意义(P>0.05)。观察组的整体有效率为 92.50%(37/40),相较于对照组的75.00%(30/40)表现出更优的效果,差异有统计学意义(P<0.05)。结论:膝痹宁Ⅱ治疗寒湿痹阻型膝骨关节炎疗效显著,能明显改善膝关节功能,缓解关节冷痛状态,减轻关节疼痛。
Abstract:
Objective:To observe the efficacy and safety of Xibining Ⅱ in the treatment of cold-dampness arthralgia type osteoarthritis.Methods:A randomized controlled single-blind method was used to divide 80 patients with knee osteoarthritis(KOA)into two groups:the control group was given celecoxib capsule orally,the observation group was given Xibining Ⅱ orally,the control group took 2 weeks,and the observation group took 4 weeks.Visual analogue scale(VAS)score,osteoarthritis index(WOMAC)score,TCM syndrome score and efficacy evaluation results were observed before and after treatment.Results:After treatment,VAS score,WOMAC total score,pain,joint function score,TCM syndrome analysis score and efficacy evaluation in the observation group were significantly lower than those in the control group(P<0.05),while there was no statistical significance in WOMAC stiffness score compared with before treatment(P>0.05).The total effective rate of the observation group was 92.50%(37/40),which was better than that of the control group 75.00%(30/40)(P<0.05).Conclusion:Xibining Ⅱ has significant effect on the treatment of cold and damp arthralgia type osteoarthritis,which can effectively improve the function of knee joint,relieve the cold pain state of joint and reduce joint pain.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(82274545)
江苏省医学重点学科/实验室建设单位项目(JSDW202252)
江苏省中医院第三批高峰学术人才项目(y2021rc02)
江苏省中医院中医膝骨关节炎临床医学创新中心项目(Y2023zx05)
山西省基础研究计划面上项目(202303021221242)
山西省中医药管理局课题(2022ZYYC277)
山西中医药大学科技创新能力培育计划项目(2022PY-ZBK-002)
山西省卫健委重点研究室建设项目(zyyyjs2024011)
△通信作者 E-mail:maojun@njucm.edu.cn
更新日期/Last Update: 2025-01-15