[1]朱烜烨,梁浩博,张蕾蕾,等.辅助性T细胞17在股骨头坏死发生发展中的作用[J].中国中医骨伤科杂志,2024,32(11):93-96.[doi:10.20085/j.cnki.issn1005-0205.241119]
　ZHU Xuanye,LIANG Haobo,ZHANG Lei Lei,et al.The Role of Helper T Cells 17 in the Development of Osteonecrosis of the Femoral Head[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(11):93-96.[doi:10.20085/j.cnki.issn1005-0205.241119]
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辅助性T细胞17在股骨头坏死发生发展中的作用()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年11期
页码:
93-96
栏目:
文献综述
出版日期:
2024-11-15

文章信息/Info

Title:
The Role of Helper T Cells 17 in the Development of Osteonecrosis of the Femoral Head
文章编号:
1005-0205(2024)11-0093-04
作者:
朱烜烨1; 2; 梁浩博1; 2; 张蕾蕾2; 贾宇东2; 刘又文1; 2
1河南中医药大学(郑州,450046)
2河南省洛阳正骨医院(河南省骨科医院)
Author(s):
ZHU Xuanye1; 2; LIANG Haobo1; 2; ZHANG Lei Lei2; JIA Yudong2; LIU Youwen1; 2
1Henan University of Chinese Medicine,Zhengzhou 450046,China; 2Luoyang Orthopedic-Traumatological Hospital of Henan Province(Henan Provincial Orthopedic Hospital),Luoyang 471000,Henan China.
关键词:
股骨头坏死;  辅助性T细胞17;  信号通路;  炎症
Keywords:
osteonecrosis of the femoral head;  helper T cell 17;  signaling pathway;  inflammation
分类号:
R681.8
DOI:
10.20085/j.cnki.issn1005-0205.241119
文献标志码:
A
摘要:
股骨头坏死是指股骨头血供中断引起骨组织坏死的一种疾病,其确切的发病机制至今尚未完全明确。辅助性T细胞17(Helper T Cell 17,Th17)作为骨免疫系统的关键细胞类型T淋巴细胞(T-lymphocyte)的亚群,在股骨头坏死的发生发展中起着至关重要的作用。概述 Th17细胞在股骨头坏死炎症反应、股骨头细胞凋亡、股骨头血管生成中的作用以及Th17细胞与其他免疫细胞的相互作用,探讨其在股骨头坏死中的作用机制。Th17细胞的调控作用可能成为股骨头坏死治疗的一种新的方向和选择,其具体机制需要进一步的实验室研究和临床验证。
Abstract:
Osteonecrosis of the femeral head(ONFH)is a disease in which the blood supply to the femoral head is interrupted and the exact pathogenesis of bone tissue is not fully understood.Helper T cell 17(Th17),as a subset of T-lymphocytes,a key cell type of the bone immune system,plays a crucial role in the occurrence and development of ONFH.This article summarizes the role of Th17 cells in ONFH inflammatory response,apoptosis of femoral head cells,angiogenesis of femoral head,and the interaction of Th17 cells with other immune cells,explores its mechanism of action in ONFH as well.The regulatory role of Th17 cells may become a new direction and option for ONFH treatment,and its specific mechanism needs further laboratory and clinical validation.

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备注/Memo

备注/Memo:
基金项目:河南省二〇二三年科技发展计划项目(232102311219)
洛阳市公益性项目行业医疗卫生专项(2022007A)
更新日期/Last Update: 2024-11-05