[1]陈鹏宇,叶超,赵久丽,等.膝骨关节炎不同证候患者关节液白介素-1β浓度特点研究[J].中国中医骨伤科杂志,2024,32(09):26-30.[doi:10.20085/j.cnki.issn1005-0205.240906]
　CHEN Pengyu,YE Chao,ZHAO Jiuli,et al.Study on the Characteristics of Interleukin-1β Concentration in Synovial Fluid of Patients with Knee Osteoarthritis with Different Syndromes[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(09):26-30.[doi:10.20085/j.cnki.issn1005-0205.240906]
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膝骨关节炎不同证候患者关节液白介素-1β浓度特点研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年09期
页码:
26-30
栏目:
临床研究
出版日期:
2024-09-15

文章信息/Info

Title:
Study on the Characteristics of Interleukin-1β Concentration in Synovial Fluid of Patients with Knee Osteoarthritis with Different Syndromes
文章编号:
1005-0205(2024)09-0026-05
作者:
陈鹏宇1; 叶超2; 赵久丽2; 张晓栋1; 刘雨煊2; 吕天成2; 赵鹏源2; 陈心怡1; 薛晓琳1△
1北京中医药大学中医学院(北京,102401)
2北京中医药大学东直门医院
Author(s):
CHEN Pengyu1; YE Chao2; ZHAO Jiuli2; ZHANG Xiaodong1; LIU Yuxuan2;  LÜ Tiancheng2; ZHAO Pengyuan2; CHEN Xinyi1; XUE Xiaolin1△
1School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102401,China;
2Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China.
关键词:
膝骨关节炎;  痰瘀互结证;  肝肾亏虚证;  关节液;  白介素-1β
Keywords:
knee osteoarthritis;  stagnation of phlegm and blood stasis syndrome;  liver and kidney deciency syndrome;  joint fluid;  interleukin-1β
分类号:
R684.3
DOI:
10.20085/j.cnki.issn1005-0205.240906
文献标志码:
A
摘要:
目的:探讨膝骨关节炎痰瘀互结证和肝肾亏虚证两种不同证候患者关节液白介素-1β(IL-1β)的浓度特点,并分析其与证候评分之间的相关性。方法:共纳入79例膝骨关节炎患者作为研究对象,根据中医证候诊断标准将患者分为痰瘀互结证组和肝肾亏虚证组,通过收集分析两组患者关节液样本,比较两组患者之间的IL-1β浓度差异,对关节液IL-1β浓度特点及其中医证候评分进行相关性分析。结果:两组患者的IL-1β浓度水平有显著差异,其中痰瘀互结证IL-1β浓度水平高于肝肾亏虚证,差异有统计学意义(P<0.05); 痰瘀互结证IL-1β浓度水平与中医证候评分正相关,差异有统计学意义(r=0.389,P<0.05); 肝肾亏虚证IL-1β浓度水平与中医证候评分无相关性,差异无统计学意义(r=0.146,P>0.05)。结论:膝骨关节炎不同证候患者IL-1β的浓度特点不同,痰瘀互结证IL-1β的浓度水平可以在一定程度上反映证候的严重程度,提示痰瘀互结证和肝肾亏虚证炎症因子的浓度差异可能反映不同的证候特点。
Abstract:
Objective:To study the characteristics of interleukin-1β(IL-1β)concentration in individuals with two distinct knee osteoarthritis syndromes,and the relationship between the syndrome score and the features of IL-1β concentration.Methods:79 patients in all with knee osteoarthritis were enrolled as the subjects.The patients were divided into two groups:stagnation of phlegm and blood stasis syndrome group and liver and kidney deficiency syndrome group according to the diagnostic criteria of traditional Chinese medicine(TCM)syndromes.The joint fluid samples of the two groups were collected and analyzed to compare the difference of IL-1β concentration in two groups,and the correlation between the concentration characteristics of IL-1β in synovial fluid and the score of TCM syndrome was analyzed.Results:The concentration of IL-1β varied significantly between the two groups,in patients with stagnation of phlegm and blood stasis syndrome,the concentration was higher than that in liver and kidney deficiency syndrome(P<0.05).The correlation between the IL-1β concentration in stagnation of phlegm and blood stasis syndrome and the syndrome score was positive and statistically significant(r=0.389,P<0.05),and there was no correlation between the syndrome score and the IL-1β concentration in liver and kidney deciency syndrome(r=0.146,P>0.05).Conclusion:The concentration features of IL-1β in synovial fluid vary across patients suffering from different syndromes.Patients with blood stasis and stagnation of phlegm syndrome may have varying concentrations of IL-1β,which may indicate a correlation between the severity of the syndrome and the characteristics of the various inflammatory factor concentrations among patients with osteoarthritis of the knee.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年科学基金项目(82104710)
北京中医药大学东直门医院青年后备人才项目(DZMG-QNHB0002)
△通信作者 E-mail:bjxuexiaol@163.com
更新日期/Last Update: 2024-09-05