[1]郑宁宁,刘振利△,薛绍鸥,等.骨膜牵张术联合抗生素骨水泥在糖尿病足治疗中的应用研究[J].中国中医骨伤科杂志,2024,32(08):18-23+28.[doi:10.20085/j.cnki.issn1005-0205.240804 ]
　ZHENG Ningning,LIU Zhenli,XUE Shaoou,et al.Application Study of Periosteal Distraction Surgery Combined with Antibiotic Bone Cement on the Treatment of Diabetes Foot[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(08):18-23+28.[doi:10.20085/j.cnki.issn1005-0205.240804 ]
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骨膜牵张术联合抗生素骨水泥在糖尿病足治疗中的应用研究()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年08期
页码:
18-23+28
栏目:
临床研究
出版日期:
2024-08-15

文章信息/Info

Title:
Application Study of Periosteal Distraction Surgery Combined with Antibiotic Bone Cement on the Treatment of Diabetes Foot
文章编号:
1005-0205(2024)08-0018-06
作者:
郑宁宁1; 刘振利1△; 薛绍鸥1; 贺达1; 刘其赞1
1河北省沧州中西医结合医院(河北 沧州,061000)
Author(s):
ZHENG Ningning1; LIU Zhenli1△; XUE Shaoou1; HE Da1; LIU Qizan1
1Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province,Cangzhou 061000,Hebei China.
关键词:
骨膜牵张术;  抗生素骨水泥;  糖尿病足;  手术指标;  足趾血氧饱和度
Keywords:
periosteal distraction surgery;  antibiotic bone cement;  diabetic foot;  surgical indicators;  toe blood oxygen saturation
分类号:
R587.2
DOI:
10.20085/j.cnki.issn1005-0205.240804
文献标志码:
A
摘要:
目的:观察骨膜牵张术联合抗生素骨水泥治疗糖尿病足(DF)的疗效。方法:按随机数字表法将糖尿病足患者66例分为两组,对照组33例予骨膜牵张术治疗,观察组33例予骨膜牵张术联合抗生素骨水泥治疗。比较手术指标、创面愈合情况、足趾血氧饱和度(SaO2)、足温、踝肱指数、疼痛程度、下肢神经传导功能、炎症因子及并发症发生情况。结果:观察组患者手术时间、术中输血量及截肢发生率与对照组差异无统计学意义(P>0.05); 创面愈合率高于对照组,差异有统计学意义(P<0.05); 溃疡愈合时间和骨窗愈合时间较对照组短,差异有统计学意义(P<0.05)。术后12周两组患者的足趾血氧饱和度、足温及踝肱指数均大于术前,差异有统计学意义(P<0.05),且观察组大于对照组,差异有统计学意义(P<0.05)。术后12周两组患者视觉模拟量表(VAS)评分均小于术前,差异有统计学意义(P<0.05),且观察组小于对照组,差异有统计学意义(P<0.05)。术后两组患者腓总神经感觉传导速度和胫神经感觉传导速度均大于术前,差异有统计学意义(P<0.05),且观察组大于对照组,差异有统计学意义(P<0.05)。术后两组患者白细胞介素(IL)-6和IL-17均小于术前,差异有统计学意义(P<0.05),且观察组小于对照组,差异有统计学意义(P<0.05)。两组患者并发症发生率比较差异无统计学意义(P>0.05)。结论:骨膜牵张术联合抗生素骨水泥可提高糖尿病足患者创面愈合率,缩短溃疡愈合时间和骨窗愈合时间,改善足趾血氧饱和度、足温、踝肱指数、下肢神经传导功能,减轻疼痛程度,降低炎症因子,且未增加并发症。
Abstract:
Objective:To observe the efficacy of periosteal distraction surgery combined with antibiotic bone cement in treating diabetes foot(DF).Methods:A total of 66 patients with DF were grouped into two groups using a random number table method.The 33 cases in control group underwent periosteal distraction surgery,while 33 cases in observation group underwent periosteal distraction surgery combined with antibiotic bone cement.Surgical indicators,wound healing,toe blood oxygen saturation(SaO2),foot temperature,ankle brachial index,degree of pain,lower limb nerve conduction function,inflammatory factors,and complications were compared.Results:There was no statistically obvious difference in surgical time,intraoperative blood transfusion volume,and amputation rate between observation group and control group(P>0.05); the wound healing rate in observation group were higher than that in control group(P<0.05),and the ulcer healing time and bone window healing time in the observation group were shorter than those in control group(P<0.05).At 12 weeks after surgery,the toe SaO2,foot temperature,and ankle brachial index of both groups were higher than before surgery(P<0.05),and observation group were higher than control group(P<0.05).At 12 weeks after surgery,the visual analogue scale(VAS)scores of both groups were lower than before surgery(P<0.05),and scores of observation group were smaller than control group(P<0.05).After surgery,the sensory conduction velocity of the common peroneal nerve and the tibial nerve in both groups were higher than before surgery(P<0.05),and observation group were higher than control group(P<0.05).After surgery,the levels of interleukin-6(IL-6)and IL-17 in both groups were lower than before surgery(P<0.05),and observation group were smaller than control group(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:The combination of periosteal distraction surgery and antibiotic bone cement can improve the wound healing rate,shorten the ulcer healing time and bone window healing time,improve toe SaO2,foot temperature,ankle brachial index,lower limb nerve conduction function,alleviate pain,reduce inflammatory factors,and do not increase the occurrence of complications in DF patients.

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备注/Memo

备注/Memo:
△通信作者 E-mail:e65zxy@163.com
更新日期/Last Update: 2024-08-05