[1]张琦,孙恒,常鑫,等.绝经后骨质疏松患者血清中脂肪细胞因子-13和成纤维细胞生长因子21的表达及其临床意义[J].中国中医骨伤科杂志,2024,32(07):57-60+68.[doi:10.20085/j.cnki.issn1005-0205.240710 ]
　ZHANG Qi,SUN Heng,CHANG Xin,et al.The Levels and Clinical Significance of Serum Apelin-13 and FGF21 in Postmenopausal Osteoporosis Patients[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2024,32(07):57-60+68.[doi:10.20085/j.cnki.issn1005-0205.240710 ]
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绝经后骨质疏松患者血清中脂肪细胞因子-13和成纤维细胞生长因子21的表达及其临床意义()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第32卷
期数:
2024年07期
页码:
57-60+68
栏目:
临床研究
出版日期:
2024-07-15

文章信息/Info

Title:
The Levels and Clinical Significance of Serum Apelin-13 and FGF21 in Postmenopausal Osteoporosis Patients
文章编号:
1005-0205(2024)07-0057-04
作者:
张琦1; 孙恒1; 常鑫1; 王佳1; 付群1; 耿涛1; 赖杰1△
1应急总医院(北京,100028)
Author(s):
ZHANG Qi1; SUN Heng1; CHANG Xin1; WANG Jia1; FU Qun1; GENG Tao1; LAI Jie1△
1Emergency General Hospital,Beijing 100020,China.
关键词:
脂肪细胞因子-13;  成纤维细胞生长因子21;  绝经后骨质疏松;  预测价值
Keywords:
adipocytokine-13;  fibroblast growth factor 21;  postmenopausal osteoporosis;  predictive value
分类号:
R68
DOI:
10.20085/j.cnki.issn1005-0205.240710
文献标志码:
A
摘要:
目的:探讨脂肪细胞因子-13(Apelin-13)和成纤维细胞生长因子21(FGF21)在绝经后骨质疏松患者血清中的表达水平及其临床意义。方法:采取前瞻性实验设计,收集2021年6月至2023年1月收治的60例绝经后骨质疏松患者作为骨质疏松组,另选取同期于本院就诊且与骨质疏松组一般资料相匹配的60例绝经后骨密度降低患者(骨密度降低组)、60例绝经后骨密度正常的健康志愿者(骨密度正常组)。比较各组血清Apelin-13和FGF21水平; Pearson法分析绝经后骨质疏松患者血清Apelin-13和FGF21水平分别与骨密度及骨代谢指标的相关性; 受试者工作特征(ROC)曲线分析血清Apelin-13和FGF21水平对绝经后骨质疏松的预测价值。结果:骨质疏松组股骨颈、股骨粗隆、腰椎骨密度以及血清Apelin-13和FGF21水平均显著低于骨密度降低组和骨密度正常组,骨密度降低组股骨颈、股骨粗隆、腰椎骨密度以及血清Apelin-13和FGF21水平均显著低于骨密度正常组,差异有统计学意义(P<0.05)。骨质疏松组血清Ⅰ型胶原C端肽β降解产物(β-CTX)和Ⅰ型原胶原氨基端延长肽(P1NP)水平显著高于骨密度降低组和骨密度正常组,差异有统计学意义(P<0.05); 骨密度降低组血清β-CTX和P1NP水平显著高于骨密度正常组,差异有统计学意义(P<0.05)。绝经后骨质疏松患者血清Apelin-13和FGF21水平分别与股骨颈、股骨粗隆、腰椎骨密度呈显著正相关,差异有统计学意义(P<0.05); 与β-CTX、P1NP呈负相关,差异有统计学意义(P<0.05)。Apelin-13和FGF21二者联合预测绝经后骨质疏松的曲线下面积(AUC)为0.903,敏感性为83.33%,特异性为86.67%,优于Apelin-13和FGF21各自单独预测(Z联合检测-Apelin-13=2.945,Z联合检测-FGF21=2.617; P=0.003,0.009)。结论:绝经后骨质疏松患者血清Apelin-13和FGF21水平显著降低,二者联合对绝经后骨质疏松有较好的预测价值。
Abstract:
Objective:To investigate the expression levels and clinical significance of adipocytokine-13(Apelin-13)and fibroblast growth factor 21(FGF21)in the serum of postmenopausal osteoporosis patients.Methods:60 postmenopausal osteoporosis patients from June 2021 to January 2023 were collected as the osteoporosis group,additionally,60 postmenopausal patients with reduced bone mineral density(reduced bone mineral density group)and 60 healthy volunteers with normal bone mineral density(normal bone mineral density group)who were treated during the same period and matched with the general information of the osteoporosis group were collected.The levels of serum Apelin-13 and FGF21 in each group were compared; Pearson method was applied to analyze the correlation between serum Apelin-13 and FGF21 levels,bone mineral density,and bone metabolism indicators in postmenopausal osteoporosis patients; Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum Apelin-13 and FGF21 levels for postmenopausal osteoporosis.Results:The bone mineral density of neck of femur,femoral trochanter,lumbar vertebrae,and the levels of serum Apelin-13 and FGF21 in osteoporosis group were obviously lower than those in reduced bone mineral density group and normal bone mineral density group,the bone mineral density of neck of femur,femoral trochanter,lumbar vertebrae and the levels of serum Apelin-13 and FGF21 in the reduced bone mineral density group were obviously lower than those in the normal bone mineral density group(P<0.05).The serum levels of β isomer of C-terminal telopeptide of typeⅠcollagen(β-CTX)and procollagen type 1 amino-terminal propeptide(P1NP)in the osteoporosis group were obviously higher than those in the reduced bone mineral density group and the normal bone mineral density group(P<0.05),the serum levels of β-CTX and P1NP in the reduced bone mineral density group were obviously higher than those in the normal bone mineral density group(P<0.05).Serum Apelin-13 and FGF21 levels in postmenopausal osteoporosis patients were obviously positively correlated with bone mineral density of neck of femur,femoral trochanter and lumbar spine(P<0.05),and obviously negatively correlated with β-CTX and P1NP(P<0.05).The combined prediction of Apelin-13 and FGF21 for postmenopausal osteoporosis had an area under the curve(AUC)of 0.903,sensitivity of 83.33%,and specificity of 86.67%,which was superior to the individual prediction of Apelin-13 and FGF21(Zcombined detection-Apelin-13=2.945,Zcombined detection-FGF21=2.617,P=0.003,0.009).Conclusion:The serum levels of Apelin-13 and FGF21 in postmenopausal osteoporosis patients are obviously decreased,and the combination of the two has good predictive value for postmenopausal osteoporosis.

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备注/Memo

备注/Memo:
基金项目:应急总医院医学发展科研基金项目(K201917)
△通信作者 E-mail:wenhuokwn3@163.com
更新日期/Last Update: 2024-07-05