参考文献/References:
[1] SETTON L A,CHEN J.Mechanobiology of the intervertebral disc and relevance to disc degeneration[J].J Bone Joint Surg Am,2006,88(Suppl 2):52-57.
[2] SETTON LA,CHEN J.Cell mechanics and mechanobiology in the intervertebral disc[J].Spine(Phila Pa 1976),2004,29(23):2710-2723.
[3] NEIDLINGER-WILKE C,GALBUSERA F,PRATSINIS H,et al.Mechanical loading of the intervertebral disc:from the macroscopic to the cellular level[J].Eur Spine J,2014,23(Suppl 3):333-343.
[4] 钟华建,唐康平,程彭超,等.椎间盘退变相关的生物应力刺激[J].中国脊柱脊髓杂志,2017,27(10):946-949.
[5] 陈江,柳根哲,徐林,等.静水压对人椎间盘髓核细胞形态及基质表达的影响[J].中国组织工程研究,2012,16(13):2281-2286.
[6] BOURQUE C W.Central mechanisms of osmosensation and systemic osmoregulation[J].Nat Rev Neurosci,2008,9(7):519-531.
[7] SAGGESE T,THAMBYAH A,WADE K,et al.Differential response of bovine mature nucleus pulposus and notochordal cells to hydrostatic pressure and glucose restriction[J].Cartilage,2018(3):1947603518775795.
[8] PALACIOMANCHENO P E,EVASHWICKROGLER T W,LAUDIER D M,et al.Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced n-cadherin expression[J].J Orthop Res,2018,36(2):788-798.
[9] 李方辉,薛少青,修焕娟,等.JNK/SAPK和p38信号转导通路在高渗透压介导的兔髓核细胞凋亡中的作用[J].复旦学报:医学版,2012,39(2):128-134.
[10] 刘瑞龙,薛少青,纪学尚,等.高渗应激下ERK信号转导通路在兔髓核细胞凋亡中的作用[J].中国矫形外科杂志,2012,20(9):838-842.
[11] KUO Y J,WU L C,SUN J S,et al.Mechanical stress-induced apoptosis of nucleus pulposus cells:an in vitro and in vivo rat model[J].J Orthop Sci,2014,19(2):313-322.
[12] LI X F,LENG P,ZHANG Z,et al.The Piezo1 protein ion channel functions in human nucleus pulposus cell apoptosis by regulating mitochondrial dysfunction and the endoplasmic reticulum stress signal pathway[J].Exp Cell Res,2017:358(2):377-389.
[13] SUN Z,GUO Y S,YAN S J,et al.CK8 phosphorylation induced by compressive loads underlies the downregulation of CK8 in human disc degeneration by activating protein kinase C[J].Lab Invest,2013,93(12):1323-1330.
[14] FENG C,FENG C,YANG M,et al.Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells[J].Int J Mol Med,2018,41(6):3316-3326.
[15] BIAN Q,MA L,JAIN A,et al.Mechanosignaling activation of TGFI2 maintains intervertebral disc homeostasis[J].Bone Res,2017,5(1):27-40.
[16] MA K G,SHAO Z W,YANG S H,et al.Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression[J].Osteoarthritis Cartilage,2013,21(12):2030-2038.
[17] ZHEN S,LUO B,LIU Z H,et al.Adipose-derived stromal cells protect intervertebral disc cells in compression:implications for stem cell regenerative disc therapy[J].Int J Biol Sci,2015,11(2):133-143.
[18] 范东伟,陈仲强,郭昭庆,等.周期性牵张应力对人椎间盘纤维环细胞合成和分解的影响[J].天津医药,2014,42(3):241-244.
[19] GILBERT H T,HOYLAND J A,MILLWARD-SADLER S J.The responseof human anulus fibrosus cells to cyclic tensile strain is frequency-dependent and altered with disc degeneration[J].Arthritis Rheum,2010,62(11):3385-3394.
[20] GAWRI R,MOIR J,OUELLET J,et al.Physiological loading can restore the proteoglycan content in a model of early IVD degeneration[J].PLoS One,2014,9(7):e101233.
[21] PAUL C P L,SCHOORL T,ZUIDERBAAN H A,et al.Dynamic and static overloading induce early degenerative processes in caprine lumbar intervertebral discs[J].PLoS One,2013,8(4):e62411.
[22] STEFANAKIS M,AL-ABBASI M,HARDING I,et al.Annulus fissures are mechanically and chemically conducive to the ingrowth of nerves and blood vessels[J].Spine,2012,37(22):1883-1891.
[23] 展嘉文,王尚全,朱立国,等.持续压力对离体培养兔脊柱运动节段终板内血管内皮生长因子及β-catenin的影响[J].中国中医骨伤科杂志,2018,26(6):1-5.
[24] WU Y,CISEWSKI S E,WEGNER N,et al.Region and strain-dependent diffusivities of glucose and lactate in healthy human cartilage endplate[J].J Biomech,2016,49(13):2756-2762.
[25] DELUCCA J F,CORTES D H,JACOBS N T,et al.Human cartilage endplate permeability varies with degeneration and intervertebral disc site[J].J Biomech,2016,49(4):550-557.
[26] 井夫杰,张静,詹红生.异常应力干预对兔颈软骨终板超微结构影响的实验研究[J].中国中医骨伤科杂志,2006,14(2):12-14.
[27] FENG C,LIU M,FAN X,et al.Intermittent cyclic mechanical tension altered the microRNA expression profile of human cartilage endplate chondrocytes[J].Mol Med Rep,2018,17(4):5238-5246.
[28] LIANG X M,HONG-GUANG XU M D,HONG W B,et al.Intermittent cyclic mechanical tension promotes degeneration of endplate cartilage via the nuclear factor-κb signaling pathway:an in vivo study[J].Orthop Surg,2016,8(3):393-399.
[29] XU H G,ZHENG Q,SONG J X,et al.Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical wnt signaling pathway and e-cadherin/β-catenin complex cross-talk[J].Osteoarthritis Cartilage,2016,24(1):158-168.
[30] XU H G,MA M M,ZHENG Q,et al.P120-Catenin protects endplate chondrocytes from intermittent cyclic mechanical tension induced degeneration by inhibiting the expression of RhoA/ROCK-1 signaling pathway[J].Spine,2016,41(16):1261-1271.
[31] EMANUEL K S,VERGROESEN P P,PEETERS M,et al.Poroelastic behaviour of the degenerating human intervertebral disc:a ten-day study in a loaded disc culture system[J].Eur Cell Mater,2015,20(29):330-341.
[32] WALTER BA,KORECKI CL,PURMESSUR D,et al.Complex loading affects intervertebral disc mechanics and biology[J].Osteoarthritis Cartilage,2011,19(8):1011-1018.
[33] WANG C,GONZALES S,LEVENE H,et al.Energy metabolism of intervertebral disc under mechanical loading[J].Journal of Orthopaedic Research Official Publication of the Orthopaedic Research Society,2013,31(11):1733-1738.
[34] HE J,FENG C,SUN J,et al.Cartilage intermediate layer protein is regulated by mechanical stress and affects extracellular matrix synthesis[J].Mol Med Rep,2018,17(4):6130-6137.
[35] ZHU L G,FENG M S,ZHAN J W,et al.Effect of static load on the nucleus pulposus of rabbit intervertebral disc motion segment in ex vivo organ culture[J].Chinese Medical Journal(English Edition),2016,2016(19):2338-2346.
[36] CHEN J,YAN W,SETTON L A.Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro[J].Matrix Biol,2004,22(7):573-583.
[37] BARBIR A,GODBURN K E,MICHALEK A J,et al.Effects of torsion on intervertebral disc gene expression and biomechanics,using a rat tail model[J].Spine,2011,36(8):607-614.
[38] PAUL C P L,SCHOORL T,ZUIDERBAAN H A,et al.Dynamic and static overloading induce early degenerative processes in caprine lumbar intervertebral discs[J].PLoS One,2013,8(4):e62411.