[1]邹泽良,缪杰佳,吴峰△,等.生血补髓汤对骨搬运术临床疗效及BMP-7和bFGF水平的影响[J].中国中医骨伤科杂志,2018,26(12):30-34.
　ZOU Zeliang MIAO Jiejia WU Feng ZHAO Chongzhi.Effect of Shengxue Busui Decoction on the Clinical Efficacy of Bone Transport and the Level of Osteogenic Factor BMP-7 and bFGF[J].Chinese Journal of Traditional Medical Traumatology & Orthopedics,2018,26(12):30-34.
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生血补髓汤对骨搬运术临床疗效及BMP-7和bFGF水平的影响()
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《中国中医骨伤科杂志》[ISSN:1005-0205/CN:42-1340/R]

卷:
第26卷
期数:
2018年12期
页码:
30-34
栏目:
临床研究
出版日期:
2018-12-03

文章信息/Info

Title:
Effect of Shengxue Busui Decoction on the Clinical Efficacy of Bone Transport and the Level of Osteogenic Factor BMP-7 and bFGF
文章编号:
1005-0205(2018)12-0030-05
作者:
邹泽良1; 缪杰佳2; 吴峰1△; 赵崇智1
1广东佛山市中医院骨科(广东 佛山,528000) 2广东佛山市第二人民医院骨科 △通信作者 E-mail:lyq2127@163.com
Author(s):
ZOU Zeliang1 MIAO Jiejia2 WU Feng1△ ZHAO Chongzhi1
1Department of Orthopedics, Foshan hospital of Traditional Chinese Medicine, Foshan 528000, Guangdong China; 2Department of orthopedics, the Second People' s Hospital of Foshan City, Foshan 528000, Guangdong China.
关键词:
生血补髓汤;  胫骨骨缺损;  骨搬运技术;  成骨因子;  临床观察
Keywords:
Shengxue Busui decoction;  tibia defect;  bone transport;  osteogenic factor;  clinical observation
分类号:
R681.8
文献标志码:
A
摘要:
目的:探讨生血补髓汤对创伤性胫骨骨缺损骨搬运术后患者临床疗效及BMP-7和bFGF水平的影响。方法:采用随机数字表法将50例创伤性胫骨骨缺损行骨搬运术后患者随机分为两组:观察组25例,术后以常规治疗和口服生血补髓汤; 对照组25例,仅以常规治疗,不服用中药。分别观察并比较两组患者术前及牵拉后4,8,12周血清中BMP-7和bFGF水平及X线片骨痂直径率(CDR),并比较两组临床疗效。结果:观察组患者牵拉后4,8及12周血清中BMP-7和bFGF水平均高于对照组,骨痂直径率CDR均高于对照组; 且观察组临床疗效优于对照组,以上差异均有统计学意义(P<0.05)。结论:对于创伤性胫骨骨缺损行骨搬运的术后患者,服用生血补髓汤能显著提高BMP-7和bFGF水平的表达,促进骨缺损区的骨痂生长,提高手术疗效,值得临床使用。
Abstract:
Objective:To explore the effect of Shengxue Busui decoction on the clinical efficacy and the level of osteogenic factor BMP-7 and bFGF after bone transport of traumatic tibial bone defect. Methods: 50 cases of traumatic bone defect of tibia were randomly divided into two groups by using a random number table method: 25 cases in the observation group were treated with Shengxue Busui decoction on the basis of routine treatment, and 25 cases in the control group were treated with routine treatment only. The serum BMP-7 and bFGF levels and the callus diameter ratio(CDR)on X-ray films were observed and compared between the two groups before operation and 4, 8 and 12 weeks after bone traction, and the clinical efficacy of the two groups was compared. Results: The levels of serum osteogenic factor BMP-7 and bFGF in the observation group at 4w, 8w and 12w after traction were all higher than those of the control group, and the callus diameter ratios(CDR)were also higher than those of the control group. The clinical efficacy of the observation group was also better than that of the control group, and the above differences were statistically significant(P<0.05). Conclusion: For patients with traumatic tibial bone defect undergoing bone transport, Shengxue Busui decoction can significantly improve the expression of osteogenic factor BMP-7 and bFGF, promote the growth of callus in the bone defect area. It can promote operative effect and is worthy of clinical application.

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备注/Memo

备注/Memo:
基金项目:广东省卫生医学科研课题(B2018221)
更新日期/Last Update: 2018-12-03